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Robert J. Lutz, Ph.D.
Chief and Chemical Engineer
Drug Delivery and Kinetics
Laboratory of Bioengineering and Physical Science
Bldg. 13, Rm. 3W 10B (Office) Rm. 3E 74 (Lab)
Tel: 301-435-1944 (Office) 301-435-9349 (Lab)
Fax: 301-496-6608
E-mail: lutzr@mail.nih.gov
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Research Interest and Expertise
- Pharmacokinetics, heat and mass transport, and fluid mechanics
- Analysis of drug kinetic data
- Application of mathematical models such as finite element methods for simulation of mass transport of drugs and other agents in physiological systems and for the simulation of heat transfer in tissue and of fluid flow in vasculature
- Use of in vitro models of vascular systems to study hemodynamic problems such as atherosclerosis and arterial drug delivery, and the development of in vitro models of tissue systems for heat and mass transfer
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Selected Publications
- Kim H, Lizak MJ, Tansey G, Csaky KG, Robinson MR, Wang NS , Lutz RJ: Study of ocular transport of drugs released from an intravitreal implant using magnetic resonance imaging. Annals of Biomedical Engineering, 33(2), 150-164, 2005.
- Kim H, Csaky KG, Gilger BC, Dunn JP, Lee SS, Tremblay M, de Monasterio F, Tansey G, Yuan P, Bungay PM, Lutz RJ, Robinson MR: Preclinical evaluation of a novel episcleral cyclosporine implant for ocular graft-versus-host disease. Invest Ophthalmol Vis Sci, Feb; 46(2):655-662, 2005.
- Yim P, Cebral J, Weaver A, Lutz RJ, Soto O, Vasbinder GB, Ho VB, Choyke PL: Estimation of differential pressure at renal artery stenosis. Magn Reson Med, 51:969-77, 2004.
- Kim H, Robinson MR, Lizak MJ, Tansey G, Lutz RJ, Yuan P, Wang NS , Csaky, KG: Controlled drug release from an ocular implant: An evaluation using dynamic 3-dimensional magnetic resonance imaging. Invest Ophthalmoy & Vis Sci, 45(8):2722-2731, 2004.
- Lutz RJ, Warren K, Balis F, Patronas N, Dedrick RL: Mixing during intravertebral arterial infusions in an in vitro model. J. Neuro-Oncol , 58: 95-106, 2002.
- Wiener SM, Hoyt Jr.,RF, Deleonardis,JR, Clevenger, RR, Jeffries K R, Nagashima, K, Mandel, M, Owens, MJ, Eckhaus, Lutz, RJ, and Safer B: Manometric changes during retrograde biliary infusion in mice AJP - GI, 279: G49, 2000.
- Darbeau MJ, Lutz RJ, Collins WE: Simulated lipoprotein transport in the wall of branched arteries. ASAIO Journal , 46 (6) 669-678, 2000.
- Peacock J, Jones T, Tock C, Lutz R: The onset of turbulence in physiological pulsatile flow in a straight tube. Experiments in Fluids, 24: 1-9, 1998.
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Patents
- Wiener SM, Hoyt RF, Deleonardis JR, Clevenger RR, Lutz RJ, Christini, DV, Safer B: "Method for pressure mediated selective delivery of therapeutic substances and cannula." US Patent application No. 09/700, 1999.
- Dedrick RL, Lutz RJ, Zaharko DS: "An Apparatus for Controlling Release of a Drug." U.S. Patent #3,946,734, March 30, 1976.
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University Theses Advised
- “Study of ocular transport of released from a sustained release implant. “ by Hyuncheol Kim, PhD Dissertation, University of Maryland, Chemical Engineering Department, May 2004.
- “Methods to study controlled drug release in the vitreous humor,” by Hyuncheol Kim, Masters Thesis, University of Maryland, Chemical Engineering Department, May 2001.
- “Macromolecular mass transfer through the porous walls of a 90° T-bifurcation and its relation to localized atherosclerosis in arterial junctions,” by Michele Darbeau, Masters Thesis, Howard University, Chemical Engineering Department, May 1998.
- “Predicting the onset of turbulence in pulsatile flow through elastic tubes,” by Beverly Smith, Masters Thesis, Howard University, Chemical Engineering Department, December 1994.
- “A laser doppler velocimetry study of the flow past a sphere in a cylindrical tube at high Reynolds number,” by Doris Jalice, Masters Thesis, Howard University, Chemical Engineering Department, April 1989.
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