Tsg101: HIV's Personal ESCRT 3 |
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| Air date: | Wednesday, October 03, 2007, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 65 minutes |
| NLM Title: | Tsg101 : HIV's personal ESCRT 3 [electronic resource] / Carol A. Carter. |
| Series: | NIH director's Wednesday afternoon lecture series |
| Author: | Carter, Carol A. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
| Other Title(s): | NIH director's Wednesday afternoon lecture series |
| Abstract: | (CIT): More than five years ago, our laboratory, and other laboratories, reported a link between the tumor suppressor protein (Tsg) 101 and the human immunodeficiency virus type 1 (HIV-1), the etiological agent of the acquired immune deficiency syndrome (AIDS). This discovery initiated a virtual explosion of new studies that have brought together the fields of endocytic trafficking and animal virology and provided potential new targets for development of antiviral agents against HIV as well as other viruses. The Gag protein encoded by HIV was found to recruit Tsg101 and its binding partners, components of endocytic sorting complexes required for transport (ESCRT). We now know that Tsg101 is required for efficient release of HIV from infected cells. Paradoxically, Tsg101 normally promotes protein endocytosis and functions with other ESCRT factors in sorting of endocytic cargo to degradative compartments in the cell. We will present evidence that non-ESCRT proteins modulate Tsg101 function to facilitate release of assembled viral proteins from budding sites at the cell periphery. |
| Subjects: | Acquired Immunodeficiency Syndrome--etiology DNA-Binding Proteins--genetics HIV-1--pathogenicity Transport Vesicles--genetics |
| Publication Types: | Government Publications Lectures |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | QW 168.5.H6 |
| NLM ID: | 101319978 |
| CIT File ID: | 14057 |
| CIT Live ID: | 6150 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14057 |
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Enhanced Audio Podcast | 58:57 |
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Enhanced Video Podcast | 58:57 | |