Genetic Condition |
Main Cancers |
Gene |
Location |
Year |
Hereditary retinoblastoma |
Retinoblastoma |
RB1 |
13q14 |
1986 |
|
Sarcomas |
|
|
|
Hereditary Wilms' tumor |
Wilms' tumor |
WT1 |
11p13 |
1990 |
Li-Fraumeni syndrome |
Breast Cancer |
TP53 |
17p13 |
1990 |
|
Sarcomas |
|
|
|
|
Brain tumor |
|
|
|
Neurofibromatosis 1 |
Sarcomas |
NF1 |
17q11 |
1990 |
|
Brain tumor |
|
|
|
Familial adenomatous |
Colon Cancer |
APC |
5q21 |
1991 |
polyposis |
Neurofibromatosis 2 |
Acoustic neuroma |
NF2 |
22q12 |
1993 |
|
Brain tumor |
|
|
|
von Hippel-Lindau |
Renal Cancer |
VHL |
3p25 |
1993 |
syndrome |
Pheochromocytoma |
|
|
|
|
Brain tumor |
|
|
|
Multiple endocrine |
Pheochromocytoma |
RET |
10q11 |
1993 |
neoplasia 2 |
Medullary thyroid cancer |
|
|
|
Tuberous sclerosis 2 |
Renal Cancer |
TSC2 |
16p13 |
1993 |
|
Brain tumor |
|
|
|
Hereditary non-polyposis |
Colon Cancer |
hMSH2 |
2p16 |
1993 |
Colon Cancer 1 |
Endometrial Cancer |
|
|
|
|
Stomach Cancer |
|
|
|
Hereditary non-polyposis |
Colon Cancer |
hMLH1 |
3p21 |
1994 |
Colon Cancer 2 |
Endometrial Cancer |
|
|
|
|
Stomach Cancer |
|
|
|
Hereditary non-polyposis |
Colon Cancer |
hPMS1 |
2q32 |
1994 |
Colon Cancer 3 |
Endometrial Cancer |
|
|
|
|
Stomach Cancer |
|
|
|
Hereditary non-polyposis |
Colon Cancer |
hPMS2 |
7p22 |
1994 |
Colon Cancer 4 |
Endometrial Cancer |
|
|
|
|
Stomach Cancer |
|
|
|
Hereditary Melanoma 1 |
Melanoma |
CDKN2 |
9p21 |
1994 |
Hereditary Breast Cancer 1 |
Breast Cancer |
BRCA1 |
17q21 |
1994 |
|
Ovarian Cancer |
|
|
|
Ataxia telangiectasia |
Breast Cancer |
ATM |
11q22-23 |
1995 |
|
Lymphoma |
|
|
|
Hereditary Breast Cancer 2 |
Breast Cancer |
BRCA2 |
13q12-13 |
1995 |
Hereditary Melanoma 2 |
Melanoma |
CDK4 |
12q13 |
1996 |