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Vlad Speransky, Ph.D. Staff Scientist Supramolecular Structure and Function Laboratory of Bioengineering and Physical Science Bldg. 13, Rm. 3W 62 Phone: 301-496-3989 Fax: 301-435-4699 E-mail: speransv@mail.nih.gov

Research Interests

Visualization of biological structure at the nanoscale. In particular:

• Electron tomography - reconstruction from multiple views of the sample in order to visualize subcellular structure in 3D. Tomography of stained plastic sections and of frozen-hydrated material, with the eventual goal of observing macromolecular complexes inside hydrated cells and tissues.
• Localizing macromolecules and chemical elements, using electron microscopy, within the context of an intact cell. Immunogold labeling, cytochemistry, in situ hybridization, X-ray microanalysis, and EELS.
• Advances in methods of specimen preparation, especially those facilitating observation of biological material in a frozen-hydrated, life-like state.
• Computer image processing and analysis. 3-D reconstruction and feature extraction algorithms. Scripting to streamline and automate routine tasks.