[CMAD Membership Roster] [CMAD Meeting Rosters]

The Cellular Mechanisms in Aging and Development [CMAD] Study Section reviews applications that address fundamental studies relating to the biological, molecular, genomic, biochemical, metabolic and physiological mechanisms that determine lifespan and longevity.  Specific areas covered by CMAD include:

• Determinants of lifespan and longevity in model organisms: caloric restriction/dietary restriction; role of insulin/IGF signaling and receptors in determining longevity.
• Theories of aging: oxidative stress; mitochondrial dysfunction; DNA damage; protein misfolding; autophagy; proteosomal degradation; apoptosis; cellular senescence; replicative senescence/cancer; telomeres and telomerase in aging.
• Genetics and epigenetics of aging including genetic manipulation of aging phenotype.
• Aging syndromes: Werner Syndrome (WS), Hutchinson Gilford Progeria Syndrome (HGPS); dyskeratosis congenita; laminopathies; other progeroid syndromes of accelerated aging.
• Immunosenescence: changes in immune function with age; thymic involution; macrophage function; inflammation.
• Adult stem cells in the replacement/repair of aging/damaged tissue.
• Muscle aging: mechanisms of signaling and satellite cell proliferation in alleviating sarcopenia.

Study sections with most closely related areas of similar science listed in rank order: 

Aging Systems and Geriatrics [ASG]
Skeletal Muscle Biology and Exercise Physiology [SMEP]
Cellular and Molecular Biology of Neurodegeneration [CMND]
Pathobiology of Kidney Disease [PBKD]
Development-1 [DEV1]