National Toxicology Program

CASRN: 98-85-1

Formula: C8-H10-O

Synonyms/Common Names:

• ALPHA-METHYLBENZENEMETHANOL (9CI)

Known Uses:

FLAVORING AGENT. FRAGRANCES. LAB REAGENT. INTERMEDIATE IN STYRENE PRODUCTION. DYES.

Short-Term Toxicity

• 14-Day (Gavage)  (C55685) Completed 
  • NTIS No. PB90-241092  (Peer Review 03/13/1989)
    Citation: Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CAS No. 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55685) Completed 
  • NTIS No. PB90-241092  (Peer Review 03/13/1989)
    Citation: Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CAS No. 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,93,1500, M: 0,46.9,750 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55685) Report Complete 
  • TR-369 (NTIS No. PB90-241092)  (Peer Review 03/13/1989)
    Toxicology and Carcinogenesis Studies ofa-Methylbenzyl Alcohol (CAS No. 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0, 375, 750 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (870290) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (570080) Completed 
  •  Positive 
• Salmonella  (377758) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative