| Monday, March 19, 2007 |
| 8:00 a.m. |
Registration |
| 8:30 – 8:50 a.m. |
Welcome and Charge to the Group
David A. Schwartz, M.D.
Director
National Institute of Environmental Health Sciences (NIEHS)
Nora D. Volkow, M.D.
Director
National Institute on Drug Abuse (NIDA) |
| 8:50 – 9:00 a.m. |
Introductions |
| 9:00 – 9:30 a.m. |
Phenotypic Plasticity and the Epigenetics of Human Disease
Andrew P. Feinberg, M.D., Ph.D.
Johns Hopkins University School of Medicine |
| 9:30 – 9:45 a.m. |
Break |
| 9:45 – 11:00 a.m. |
Scientific Session 1: Applications to Human Health and Disease
How Can the Application of Epigenetic Approaches Advance Our Understanding of Disease Susceptibility and Pathogenesis? |
| 9:45 – 10:10 a.m. |
Mixed Epigenetic/Genetic and De novo/Inherited (MEGDI)
Models of Disease
Arthur L. Beaudet, M.D.
Baylor College of Medicine |
| 10:10 – 10:35 a.m. |
Epigenetics and Autoimmunity
Bruce Richardson, M.D., Ph.D.
University of Michigan |
| 10:35 – 11:00 a.m. |
Epigenetic Mechanisms of Drug Addiction
Eric J. Nestler, M.D., Ph.D.
University of Texas, Southwestern |
| 11:00 – 11:15 a.m. |
Break |
| 11:15 – 12:30 p.m. |
Scientific Session 2: The State of Epigenetic Technology
What Technologies and Investigative Approaches to Research Are Available and Likely To Be of Value in Epigenetics? |
| 11:15 – 11:40 a.m. |
Overview of Epigenetic Analysis Technologies
Peter W. Laird, Ph.D.
University of Southern California |
| 11:40 a.m. – 12:05 p.m. |
Genome-wide Transcription Maps Reveal Interleaved Organization and Possible Functions for Pervasive Transcription
Thomas R. Gingeras, Ph.D.
Affymetrix, Inc. |
| 12:05 – 12:30 p.m. |
Mapping the Genome’s Second Code
Bing Ren, Ph.D.
University of California, San Diego |
| 12:30 – 1:45 p.m. |
Lunch (on your own) |
| 1:45 – 2:45 p.m. |
Overview: International and U.S. Epigenetics Programs and Resources |
| 1:45 – 2:00 p.m. |
European Epigenetics Programs
Stephan Beck, Ph.D.
Wellcome Trust Sanger Institute |
| 2:00 – 2:15 p.m. |
Epigenetics Bioinformatics Resources
Paul Flicek, D.Sc.
European Bioinformatics Institute |
| 2:15 – 2:30 p.m. |
Canadian Epigenetics Programs
Art Petronis, M.D., Ph.D.
University of Toronto |
| 2:30 – 2:45 p.m. |
Epigenetics and the ENCODE Project
Elise A. Feingold, Ph.D.
National Human Genome Research Institute |
| 2:45 – 3:00 p.m. |
Break |
| 3:00 – 3:10 p.m. |
Criteria for Roadmap Proposals
Elizabeth Wilder, Ph.D.
Office of Portfolio Analysis and Strategic Initiatives (OPASI) |
| 3:10 – 5:10 p.m. |
Breakout Session 1: Generation of Epigenetics Suggestions
Breakout Discussion Group A
Chair: David Schwartz, M.D., NIEHS Director
Presenter: Steven Baylin, M.D.
Breakout Discussion Group B
Chair: Nora Volkow, M.D., NIDA Director
Presenter: Donata Vercelli, M.D.
Breakout Discussion Group C
Chair: James Battey, M.D., Ph.D., NIDCD Director
Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D. |
| 3:10 – 3:50 p.m. |
Generate three novel Roadmap suggestions for epigenetics research that could transform the biology of human health and disease, encompassing translational and clinically-oriented approaches. |
| 3:50 – 4:30 p.m. |
Generate three novel Roadmap suggestions for tools and resources that could transform epigenetics research. |
| 4:30 – 5:10 p.m. |
Generate three novel Roadmap suggestions for technological and bioinformatics needs that could transform epigenetics research. |
| 5:10 – 5:25 p.m. |
Break |
| 5:25 – 5:40 p.m. |
Breakout Group A Report
Presenter: Steven Baylin, M.D. |
| 5:40 – 5:55 p.m. |
Breakout Group B Report
Presenter: Donata Vercelli, M.D. |
| 5:55 – 6:10 p.m. |
Breakout Group C Report
Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D. |
| 6:10 – 6:30 p.m. |
Group Discussion
Facilitators: James Battey, M.D., Ph.D., Andrew Feinberg, M.D., Ph.D. and Jim Ostell, Ph.D. |
| 6:30 – 6:45 p.m. |
Response to Suggestions
David Schwartz, M.D., NIEHS Director
Nora Volkow, M.D., NIDA Director |
| 6:45 p.m. |
Adjournment |
| Tuesday, March 20, 2007 |
| 7:30 a.m. |
Registration |
| 8:00 – 9:45 a.m. |
Breakout Session 2: Implementation of Suggestions |
| 8:00 – 8:35 a.m. |
Implement a suggestion for a technology/bioinformatics opportunity that could transform epigenetics research. |
| 8:35 – 9:10 a.m. |
Implement a suggestion for a tool or resource that could transform epigenetics research. |
| 9:10 – 9:45 a.m. |
Implement a suggestion for an application of epigenetics that could transform biology or treatment of disease. |
| 9:45 – 10:00 a.m. |
Break |
| 10:00 – 10:20 a.m. |
Breakout Group A Report
Presenter: Steven Baylin, M.D. |
| 10:20 – 10:40 a.m. |
Breakout Group B Report
Presenter: Donata Vercelli, M.D. |
| 10:40 – 11:00 a.m. |
Breakout Group C Report
Presenters: Randy Jirtle, Ph.D. and Jim Ostell, Ph.D. |
| 11:00 – 11:15 a.m. |
Break |
| 11:15 a.m. – 12:15 p.m. |
Group Discussion and Refinement of Suggestions
Facilitators: James Battey, M.D., Ph.D., Andrew Feinberg M.D., Ph.D. and Jim Ostell, Ph.D. |
| 12:15 – 12:30 p.m. |
Response to Suggestions and Closing Remarks
David Schwartz, M.D., NIEHS Director
Nora Volkow, M.D., NIDA Director |
| 12:30 p.m. |
Adjournment |
