The caBIO domain model and architecture is an ongoing effort to model the rapidly-changing genomics and proteomics domain and to integrate data from numerous sources providing a holistic view of the human and mouse genomes. The integration of genome annotations with clinical trials, pathway, and literature associations allows researchers to discover associations in the data that were previously unseen in the separate datasets thereby enhancing cancer research and drug design.

In caBIO, information is modeled as close to the corresponding biological entities as possible to enable better usability for researchers and application developers alike.  Access to this data is provided through a variety of interfaces, including a remote Java API; web services (SOAP and REST API); grid data services available on caGrid; and graphical user interfaces (GUIs) including a caBIO web page and caBIO Portlet available through the caGrid Portal.  GUI tools allow researchers to perform a Google ™-like FreestyleLM search that provides end-users with a simple interface to readily browse the contents of the repository.  Templated based searches are also available via the caBIO Portlet and allow researchers to execute common queries based on pre-defined templates.

The data in caBIO is updated on a monthly basis to ensure that most up-to-date view of these data sources is available.