Testing Status of Agents at NTP
Methacrylonitrile
CASRN: 126-98-7
Formula: C4 H5 N
Synonyms/Common Names:
- MAN
- 2-PROPENENITRILE, 2-METHYL- (9CI)
Known Uses:
HOMO- AND CO-POLYMERS, ELASTOMERS, COATINGS AND PLASTICS. CHEMICAL INTERMEDIATE. REPLACEMENT FOR ACRYLONITRILE IN CERTAIN USES. (NTP EXECUTIVE SUMMARY)
Short-Term Toxicity
- 2-WEEK (Gavage)
(C88050) Completed
- TOX-47 (NTIS No. PB2000-106-406)
(Toxicity Peer Review 11/08/1999)
Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1Mice (CAS No. 126-98-7) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 0.3, 0.6, 1.2, 2.4, 4.8 G/L; M: 0, 0.15, 0.3, 0.6, 1.2, 2.4 G/L; 5/GRP
- TOX-47 (NTIS No. PB2000-106-406)
(Toxicity Peer Review 11/08/1999)
- 13-WEEK (Gavage)
(C88050) Report Complete
- TOX-47 (NTIS No. PB2000-106-406)
(Toxicity Peer Review 11/08/1999)
Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1Mice (CAS No. 126-98-7) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,7.5,15.0,30.0,60.0,120.0 MG/KG/DAY; M: 0,0.75,1.5,3.0,6.0,12.0 MG/KG/DAY; RATS: 20/GRP; MICE: 10/GRP
- TOX-47 (NTIS No. PB2000-106-406)
(Toxicity Peer Review 11/08/1999)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C88050B) Report Complete
- TR-497 (NTIS No. PB2002-102199)
(Peer Review 05/03/2001)
Toxicology and Carcinogenesis Studies of Methacrylonitrile (CAS No. 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES
- TR-497 (NTIS No. PB2002-102199)
(Peer Review 05/03/2001)
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage)
(S0679) Completed
- Citation: GHANAYEM, B.I., SANCHEZ, I.M., BURKA, L.T., EFFECTS OF DOSE, STRAIN & DOSING VEHICLE ON METHACRYLONITRILE DISPOSITION IN RATS & IDENTIFICATION OF A NOVEL-EXHALED METABOLITE: DRUG METAB & DISP. VOL 20, #5, 643-652, 1992
- M Rats: F344/N; M Rats: Sprague Dawley
- Dose: 1.15, 11.5, 115 mg/kg
- Absorption Disposition Metabolism Elimination
(S0730) Completed
- Citation: BURKA, L.T., SANCHEZ, I.M., AMED, A.E., GHANAYEM, B.I., COMPARATIVE METABOLISM AND DISPOSITION OF ACRYLONITRILE AND METHACRYLONITRILE IN RATS, ARCH TOXICOL 68: 611-618, 1994
- M Rats: F344/N
- Metabolism
(S0727) Completed
- Citation: GHANAYEM, B. I., & BURKA, L.T., EXCRETION AND IDENTIFICATION OF METHACRYLONITRILE METABOLITES IN THE BILE OF MALE F344 RATS DRUG METABOLISM AND DISPOSITION , VOL 24, #4, 390-394, 1996
- M Rats: F344/N
- Other
(S0728) Completed
- Citation: DEMBY, K.B., WHITE, T.C., GHANAYEM, B.I., DETERMINATION OF METHACRYLONITRILE IN SERUM USING GAS CHROMATOGRAPHY AND FLAME IONIZATION DETECTION, JRNL OF CHROMATOGRAPHY, 579, 1992, 153-157
- Toxicokinetic Study
(S0729) Completed
- Citation: DEMBY, K.B., SANCHEZ, I.M., & GHANAYEM, B.I., SINGLE DOSE BLOOD TOXICOKINETCS OF METHACRYLONITRILE IN THE F344 RAT, TOXICOLOGY & APPLIED PHARMACOLOGY 119, 115-121 (1993)
- M Rats: F344/N
Genetic Toxicology
- Drosophila
(042416) Completed
- Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Micronucleus
(A05400) Completed
- Rats: F344
- Male Negative
- Micronucleus
(A38969) Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A63179) Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(799133) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Negative
- Salmonella
(926215) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Negative
Organ Systems Toxicity
- 16 WEEKS Continuous Breeding (Gavage)
(RACB94019) Completed
- NTIS No. PB97-176390
Citation: Reproductive Toxicity of Methacrylonitrile (CAS # 125-98-7) Administered in Diet to Sprague-Dawley Rats - M/F Rats: Sprague Dawley
- Dose: 0, 2, 7, OR 20 MG/KG
- NTIS No. PB97-176390
- Conventional Teratology (Gavage)
(TER92117) Completed
- NTIS No. PB93-190072
Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats - Rats: Sprague Dawley
- Rats Maternal Negative
- Rats Fetal Negative
- Dose: 0, 5, 25, 50 MG/KG GD: 6-15
- NTIS No. PB93-190072
- GESTATIONAL DAYS 6 - 19 Conventional Teratology (Gavage)
(TER92122) Completed
- NTIS No. PB93-196061
Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in New Zealand White Rabbits - Rabbit: New Zealand White
- Rabbits Maternal Negative
- Rabbits Fetal Negative
- Dose: 0, 1, 3, 5 MG/KG/DAY
- NTIS No. PB93-196061
- Teratology Pilot Studies (Gavage)
(TRP91020) Completed
- Rabbit: New Zealand White
- Dose: 0, 5, 10, 25, 50, 75 MG/KG
- GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)
(TRP91021) Completed
- F Rats: Sprague Dawley
- Dose: 0, 10, 50, 75, 100, 125 MG/KG
- GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)
(TRP92058) Completed
- F Rabbit: New Zealand White
- Dose: 0 OR 7.5 MG/KG
Web page last updated on January 22, 2009