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Animal Study Proposal Development and Forms
Animal Study Proposal Form (download here)
Modification Form (download here)
ASP Instruction form
 Standard Language and Terminology for ASPs
How does the LASP-Bethesda help you with the ACUC review process for your research studies?
The LASP-Bethesda staff provides consultation services to help
the investigator prepare an Animal Study Proposal (ASP) that will
proceed through the ACUC review process in a timely manner.
We can help you with the design, animal model selection,
analgesia/anesthesia, as
well as address animal welfare, care, and health issues before the
study is submitted to the ACUC for review and approval. Ideally, one of the
LASP-Bethesda veterinarians and the ACUC Coordinator meets with the investigator (well before the ACUC
deadline for submission) and provides input for the animals use aspects of the
ASP. We suggest you contact the LASP-Bethesda veterinarian or the ACUC Coordinator at least one
month before the deadline for submitting your proposal to the ACUC.
This
process facilitates quick turn around for ASP approval and allows investigators
to begin their research with minimal delay. Please see here for a schedule of
submission deadlines and ACUC meetings.
.
Suggested Method For Developing An ASP
- The investigator develops an
idea for a study.
- The investigator uses the
LASP-Bethesda website and/or contacts the LASP-Bethesda veterinarian and/or ACUC Coordinator for
guidance on specific animal issues and helpful language for their study.
- The investigator completes a
draft of the Animal Study Proposal.
- The investigator submits a
copy to Lab Animal Sciences Program - Bethesda one month before the meeting.
- The LASP-Bethesda veterinarian and ACUC Coordinator
conduct a pre-review of the Animal Study Proposal and request any necessary
clarifications from the PI to fine-tune it for the meeting.
- Necessary revisions are made
at the latest one week before the meeting and distributed to ACUC members.
Key Points To Remember For ASP Development
Use
the current NCI ASP
form. In order to comply with
various regulations, the LASP-Bethesda form frequently requires updating and
modification. To ensure you are working with the most recent version of the
form, please work with the form directly from this site.
Save your
electronic ASP form to facilitate modifications and
renewals.
Investigators must document they have considered
alternatives to procedures listed for Category 2 and 3 studies that may cause
more than momentary or slight pain or distress to the animals whether alleviated (Category 2) or not (Category
3). Also, the investigator must indicate that alternatives were not available,
or justify why alternatives found are not appropriate for the study.
A
database search is an effective tool for providing this information to the ACUC.
We recommend using
Alternatives to Animal Testing
when searching for this information. Once completed, you will need
to indicate in Section G on the ASP form: the databases searched, the date the search was conducted, the
key words used, the period covered by the search, and a brief narrative of the
results. The
NIH Library
is an excellent resource to assist you and will perform the
search. A
tutorial
is also offered.
Provide information
as requested in the direction on the ASP form. Following suggestions provided
on the ASP handout will help get your
ASP through the ACUC review in a timely manner.
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