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Re: A rather painful study design...

Author: Daniel Schwartz (137.53.24.---)
Date: 01-26-09 11:56

Okay, so there are 5 CONDITIONs that each subject completes:

Stop
UpLeft
UpRight
DownLeft
DownRight

I would like to examine a couple of contrasts here:

(UpLeft +UpRight + DownLeft + DownRight) > Stop
(UpLeft + UpRight) > (DownLeft + DownRight)
(UpLeft + DownLeft) > Stop

Then I would like to examine whether the differences in these contrasts vary over GROUP at the two applicable timepoints after treatment (Immediate and 6Month), for instance:

Controls((UpLeft + DownLeft) > Stop) > Patients((UpLeft + DownLeft) > Stop)

Then I would like to do a GROUP x TIME interaction effect for the contrasts listed above (Including the 6Week scan that the Patients got but the Controls didn't?).

Then I would like to look within the Patient group to try and characterize a timecourse of recovery from treatment, asking specifically if the change is linear over time after treatment:

Patient-Immediate(SomeContrast) > Patient-6Week(SomeContrast) > Patient-6Month(SomeContrast)

Besides these, I'm sure I could come up with plenty of other meaningful contrasts... but these are the specific hypotheses.

Thankyou for your help! I'm not THAT scared of R, by the way... if I should be doing this in R, that's okay, but some help on how to set it up would be awesome.

You guys are the best.
-Daniel

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