| Disease/Syndrome |
Liver cancer |
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| Category |
Cancer, Occupational |
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| Acute/Chronic |
Chronic |
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| Synonyms |
Hepatocellular carcinomas (HCC); Angiosarcoma of the liver (ASL); Hemangiosarcoma of the liver is an older term for ASL; |
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| Biomedical References |
Search PubMed |
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| Comments |
There were negative associations between ionizing radiation and liver cancer in studies of radium dial painters, radiologists, underground miners, nuclear workers, uranium processors, and Mayak workers. There was strong evidence that Thorotrast (Th-232) caused liver cancer when used as a radiographic contrast agent between 1928 and 1955. [Boice, p. 261, 271] Hepatocellular carcinomas (HCC) comprise about 75% to 90% of liver cancers. "Eighty to 95% of HCCs are associated with chronic infection of hepatocytes with either of two viruses, hepatitis B virus (HBV) or hepatitis C virus (HCV)." Increased risk of angiosarcoma of the liver (ASL) was found in workers exposed to vinyl chloride while cleaning reactor vessels for the production of polyvinyl chloride. There is suggestive evidence that German vineyard workers exposed to arsenic in the 1930s and 1940s had increased incidence of angiosarcoma of the liver. [Schottenfeld, p. 763, 773] |
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| Latency/Incubation |
Months to years |
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| Diagnostic |
Bone marrow examination |
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| ICD-9 Code |
155 |
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| Related Information in Haz-Map |
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| Agents |
Hazardous agents that cause the occupational disease:
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