Summaries & Associations of Study Results
TR-528 2,2-bis(Bromomethyl)-1,3-Propanediol, Nitromethane, and 1,2,3-Trichloropropane
Target Organs and Levels of Evidence
NTP Technical Report Number 528
Produced from Chemtrack Database 05/14/04
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| FISH PROJECT 1 (NITROMETHANE) 75-52-5 |
02/18/04 | SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES. | Aqueous Exposure 9.4, 21, OR 46.6 MG/L 160 FISH/DOSE/SPECIES | Gulf Coast Research Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| M: NEGATIVE | ||||
| F: NEGATIVE | ||||
| FISH PROJECT 1 (NITROMETHANE) 75-52-5 |
02/18/04 | SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES. | Aqueous Exposure 10.8, 30.9, OR 88.4 MG/L 160 FISH/DOSE/SPECIES | Gulf Coast Research Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| M: INCONCLUSIVE | ||||
| F: NEGATIVE | ||||
| FISH PROJECT 1 (2,2-BIS(BROMOMETHYL)-1,3- PROPANEDIOL) 3296-90-0 |
02/18/04 | SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES. | Aqueous Exposure 160 FISH/DOSE/SPECIES | Gulf Coast Research Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| M: POSITIVE | LIVER (CORE STUDY): ADENOMA 3/61 4/50 4/41 8/38 ADENOMA OR CARCINOMA 4/61 6/50 6/41 10/38 | |||
| LIVER (STOP-EXPOSURE STUDY): ADENOMA 0/28 3/22 3/21 6/24 ADENOMA OR CARCINOMA 0/28 3/22 3/21 9/24 | ||||
| F: INCONCLUSIVE | ||||
| FISH PROJECT 1 (2,2-BIS(BROMOMETHYL)-1,3- PROPANEDIOL) 3296-90-0 |
02/18/04 | SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES. | Aqueous Exposure 0, 24, 60, 150 MG/L 160 FISH/DOSE/SPECIES | Gulf Coast Research Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| M: POSITIVE | LIVER (CORE STUDY): ADENOMA 1/47 0/59 0/56 6/59 ADENOMA OR CARCINOMA 1/47 0/59 0/56 8/59 | |||
| LIVER (STOP-EXPOSURE STUDY): ADENOMA 1/27 0/21 1/31 3/29 ADENOMA OR CARCINOMA 1/27 0/21 1/31 4/29 | ||||
| F: NEGATIVE | ||||
| FISH PROJECT 1 (1,2,3-TRICHLOROPROPANE) 96-18-4 |
02/18/04 | SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES. | Aqueous Exposure 0, 4.5, 9, OR 18 MG/L (2 REPLICATES PER TREATMENT GROUP) 170/FISH/EACH REPLICATE AQUARIUM | Gulf Coast Research Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| M: POSITIVE | LIVER (CORE STUDY): CHOLANGIOCARCINOMA 0/61 0/47 0/67 3/27 ADENOMA 3/61 8/47 17/67 9/27 CARCINOMA 0/61 1/47 0/67 7/27 ADENOMA OR CARCINOMA COMBINED 3/61 9/47 17/67 15/27 | |||
| LIVER (STOP-EXPOSURE STUDY): CHOLANGIOCARCINOMA 0/32 0/19 0/26 1/19 ADENOMA 3/32 4/19 5/26 7/19 CARCINOMA 0/32 0/19 1/26 4/19 ADENOMA OR CARCINOMA COMBINED 3/32 4/19 5/26 10/19 | ||||
| F: POSITIVE | LIVER (CORE STUDY): CHOLANGIOMA 0/64 3/64 4/47 2/33 CHOLANGIOCARCINOMA 0/64 0/64 0/47 6/33 ADENOMA OR CARCINOMA 5/64 4/64 4/47 8/33 | |||
| LIVER (STOP-EXPOSURE STUDY): CHOLANGIOMA 2/31 2/31 0/31 2/27 CHOLANGIOCARCINOMA 0/31 0/31 0/31 5/27 ADENOMA OR CARCINOMA 2/31 1/31 2/31 3/27 | ||||
| FISH PROJECT 1 (1,2,3-TRICHLOROPROPANE) 96-18-4 |
02/18/04 | SPECIAL STUDY TO EVALUATE THE UTILITY OF THE SMALL FISH MODELS IN HAZARD CHARACTERIZATION AND HOW IT CAN BE RELATED TO RODENT STUDIES. | Aqueous Exposure 0, 4.5, 9, OR 18 MG/L (2 REPLICATES PER TREATMENT GROUP) 170/FISH/EACH REPLICATE AQUARIUM | Gulf Coast Research Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| M: POSITIVE | LIVER (CORE STUDY): CHOLANGIOMA 0/95 6/94 2/65 1/78 CHOLANGIOCARCINOMA 0/95 32/94 43/65 45/78 ADENOMA OR CARCINOMA 0/95 2/94 1/65 6/78 HEPATOCHOLANGIOCARCINOMA 0/95 0/94 2/65 6/78 | |||
| LIVER (STOP-EXPOSURE STUDY): CHOLANGIOMA 0/42 0/47 3/33 1/46 CHOLANGIOCARCINOMA 0/42 19/47 16/33 26/46 ADENOMA 0/42 1/47 0/33 0/46 ADENOMA OR CARCINOMA 0/42 2/47 0/33 1/46 | ||||
| GALLBLADDER (CORE STUDY): ADENOMA, PAPILLARY 0/91 0/83 4/61 9/72 | ||||
| GALLBLADDER (STOP-EXPOSURE STUDY): ADENOMA, PAPILLARY 0/41 0/42 3/30 4/46 | ||||
| F: POSITIVE | LIVER (CORE STUDY): CHOLANGIOCARCINOMA 0/95 29/93 53/94 41/67 ADENOMA 1/95 1/93 5/94 8/67 CARCINOMA 1/95 1/93 2/94 5/67 ADENOMA OR CARCINOMA 2/95 2/93 7/94 13/67 HEPATOCHOLANGIOCARCINOMA 0/95 0/93 4/94 7/67 | |||
| LIVER (STOP-EXPOSURE STUDY): CHOLANGIOCARCINOMA 1/57 15/44 31/49 21/31 ADENOMA 4/57 2/44 2/49 1/31 CARCINOMA 0/57 2/44 1/49 4/31 ADENOMA OR CARCINOMA 4/57 4/44 2/49 5/31 HEPATOCHOLANGIOCARCINOMA 0/57 0/44 0/49 1/31 | ||||
| GALLBLADDER (CORE STUDY): ADENOMA, PAPILLARY 0/85 1/80 5/88 6/65 | ||||
| GALLBLADDER (STOP-EXPOSURE STUDY): ADENOMA, PAPILLARY 0/56 1/40 1/45 1/30 | ||||
Web page last updated on February 10, 2006
