LKB1 kinase: master and commander of metabolism and polarity.
Department of Medical Oncology, Guy's Hospital, St Thomas's Street, London SE1 9RT, UK.
LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes. Recent data have revealed novel functions for LKB1, providing new insight into the regulation of cell polarity and energy-generating metabolism.
PMID: 15186763 [PubMed - indexed for MEDLINE]