LKB1 kinase: master and commander of metabolism an...[Curr Biol. 2004]

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1: Curr Biol. 2004 May 25;14(10):R383-5. Links

LKB1 kinase: master and commander of metabolism and polarity.

Spicer J, Ashworth A.

Department of Medical Oncology, Guy's Hospital, St Thomas's Street, London SE1 9RT, UK.

LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes. Recent data have revealed novel functions for LKB1, providing new insight into the regulation of cell polarity and energy-generating metabolism.

PMID: 15186763 [PubMed - indexed for MEDLINE]

ReviewThe LKB1 tumor suppressor kinase in human disease. [Biochim Biophys Acta. 2007]
ReviewLKB1, the multitasking tumour suppressor kinase. [J Clin Pathol. 2005]
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. [Hum Mol Genet. 2005]
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. [Cell. 2004]
ReviewLKB1-dependent signaling pathways. [Annu Rev Biochem. 2006]

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