Testing Status of Agents at NTP
Phenylephrine hydrochloride
CASRN: 61-76-7
Formula: C9-H13-N-O2.CL-H
Synonyms/Common Names:
- (R)-3-HYDROXY-ALPHA-((METHYLAMINO)METHYL)-BENZENEMETHANOL HYDROCHLORIDE (9CI)
Known Uses:
SYMPATHOMIMETIC AMINE, NASAL DECONGESTANT, MYDRIATIC
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C55641) Completed
- NTIS No. PB87-208609
(Peer Review 03/26/1986)
Citation: Toxicology and Carcinogenesis Studies of Phenylephrine Hydrochloride (CAS No. 61-76-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB87-208609
(Peer Review 03/26/1986)
- 13-Week (Dosed-Feed)
(C55641) Completed
- NTIS No. PB87-208609
(Peer Review 03/26/1986)
Citation: Toxicology and Carcinogenesis Studies of Phenylephrine Hydrochloride (CAS No. 61-76-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,1250,20000 PPM/10 PER GROUP
- NTIS No. PB87-208609
(Peer Review 03/26/1986)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C55641) Report Complete
- TR-322 (NTIS No. PB87-208609)
(Peer Review 03/26/1986)
Toxicology and Carcinogenesis Studies of Phenylephrine Hydrochloride (CAS No. 61-76-7) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0,620,1250 M: 0,1250,2500 PPM/50 PER GROUP
- TR-322 (NTIS No. PB87-208609)
(Peer Review 03/26/1986)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(766784) Completed
- Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Mouse Lymphoma
(106595) Completed
- Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
- Positive
- Micronucleus
(A44702) Completed
- Rats: F344
- Male Negative
- Salmonella
(133081) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Negative
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