This is a summary
of the most important information about Ranexa. For details,
talk to your healthcare professional.
What
Is Ranexa?
Ranexa is
used to treat adults with chronic chest pain (angina). Ranexa
can cause a serious heart beat problem called QT prolongation.
Because of this problem, Ranexa should only be used after other
angina medicines have not relieved chest pain symptoms. Ranexa
should be used with amlodipine (Norvasc), beta blocker
medicines, or nitrate medicines. Ranexa does not relieve sudden
chest pain.
Chronic
chest pain (angina) is caused by not enough blood flow to the
heart. Ranexa has not been studied in children.
Who Should Not Take Ranexa?
Do not take
Ranexa if you:
- have a
heart problem called QT prolongation
- have or
had liver problems
- are
taking other medicines that also cause QT prolongation. Some
of these medicines are:
-
antiarrhythmic medicines including quinidine, dofetilide (Tikosyn),
sotalol (Betapace)
-
erythromycin
-
certain antipsychotic medicines including thioridazine (Mellaril),
ziprasidone (Geodon)
- are
taking medicines or foods that can interact with Ranexa. Some
of these include:
- ketoconazole (Nizoral)
and certain other antifungal medicines
-
diltiazem (Cardiazem, Dilacor, Tiazac)
-
verapamil (Calan, Verelan, Covera HS)
-
macrolide
antibiotics
-
HIV protease
inhibitors
-
grapefruit juice
or grapefruit containing products
What Are The Risks?
The
following are the major potential risks and side
effects of Ranexa therapy. However, this list is not
complete.
The following are the major
possible risks and side effects of
Ranexa therapy:
- QT
prolongation.
Ranexa may cause this serious heart beat problem which can
lead to sudden death.
-
dizziness and lightheadedness.
Do not drive a car or operate machinery until you know how
Ranexa affects you. Call your healthcare professional if you
have heart beat problems (palpitations) or fainting spells.
- Some
common side effects
with Ranexa include:
- headache
- constipations
- nausea
What
Should I Tell My Healthcare Professional?
Before you start taking Ranexa,
tell your healthcare professional if you:
- have or
had liver problems
- have or
had kidney problems
- have or
had heart problems
- have a
medical condition that may affect the heart, such as low blood
potassium (hypokalemia)
- are
trying to become pregnant, are already pregnant, or are
breast-feeding
Can Other
Medicines Or Food Affect Ranexa?
See “Who
should not take Ranexa?” for more information. Other medicines
not listed in that section can also interact with Ranexa
including:
-
digoxin (Lanoxin, Lanoxicaps)
-
simvastatin (Zocor)
-
ritonavir (Norvir)
-
cyclosporine (Gengraf, Neoral,
Restasis, Sandimmune)
-
antidepressant medicines
-
antipsychotic medicines
Tell your
healthcare professional about all the medicines you take
including prescription and non-prescription medicines, vitamins,
and herbal supplements. Know the medicines you take. Keep a
list of them with you to show your healthcare professional.
How Should I Take Ranexa?
- Take
Ranexa with or without meals.
- Swallow
Ranexa whole. Do not crush, break or chew the tablets.
- If you
miss a dose of Ranexa, wait until the next scheduled dose and
get back on schedule with your usual dose. Do not take more
than your usual dose at any time, even if you have missed
doses.