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Model Detail

   
Mouse Model Information
Model Name Msh2 (G674A) ATPase
Investigator Raju Kucherlapati
Status available
Availability n/a
Strain n/a
Species of Origin None selected
Mutation Type None selected
Manipulation Type targeted
Conditional n/a
Projected Use SNP assessment, GI cancer
Phenotype Summary Mice that are homozygous for the variant are viable and fertile. Cells from these mice show lack of DNA mismatch repair function but respond to DNA damaging agents appropriately. The mice are tumor prone.
Genetic Information
Gene Name mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Gene Symbol MSH2
Reference Sequence 6678937 Exiting the NIEHS site
MGI Gene Record Msh2 Gene Detail Exiting the NIEHS site
LocusLink 17685 Exiting the NIEHS site
Disease n/a
OMIM 120435 Exiting the NIEHS site
Gene Models n/a
Biopathways n/a
Gene Ontology
Molecular Function DNA binding Exiting the NIEHS site
Biological Process DNA Repair Exiting the NIEHS site
Cellular Component nucleus Exiting the NIEHS site
Publications
Title n/a
   
USA.gov Department of Health & Human Services National Institutes of Health
This page URL: http://tools.niehs.nih.gov/genotype/detail.cfm
NIEHS website: http://www.niehs.nih.gov/
Email the Web Manager at webmanager@niehs.nih.gov
Last Reviewed: 21 August 2007