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Model Detail

   
Mouse Model Information
Model Name MIh1 null
Investigator Raju Kucherlapati
Status available
Availability n/a
Strain n/a
Species of Origin None selected
Mutation Type Null
Manipulation Type targeted
Conditional N
Projected Use Tool, GI cancer
Phenotype Summary Mlh1 null mice are viable. Homozygotes are sterile. Both heterozygous and homozygous mice show cancer predisposition. They develop lymphomas, gastrointestinal tumors and tumors at other anatomical sites
Genetic Information
Gene Name mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
Gene Symbol MLH1
Reference Sequence 19387851 Exiting the NIEHS site
MGI Gene Record Mlh1 Gene Detail Exiting the NIEHS site
LocusLink 17350 Exiting the NIEHS site
Disease n/a
OMIM 120436 Exiting the NIEHS site
Gene Models n/a
Biopathways n/a
Gene Ontology
Molecular Function DNA repair
Biological Process DNA mismatch repair
Cellular Component n/a
Publications
Title n/a
   
USA.gov Department of Health & Human Services National Institutes of Health
This page URL: http://tools.niehs.nih.gov/genotype/detail.cfm
NIEHS website: http://www.niehs.nih.gov/
Email the Web Manager at webmanager@niehs.nih.gov
Last Reviewed: 21 August 2007