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Model Detail

Mouse Model Information
Model Name	Ku70 null
Investigator	Warren Ladiges
Status	available
Availability	n/a
Strain	129X1/SvJ
Species of Origin	None selected
Mutation Type	Null
Manipulation Type	targeted
Conditional	N
Projected Use	n/a
Phenotype Summary	Ku70-deficient mice were about 50% size of control littermates and their fibroblasts were ionizing sensitive and deisplayed premature senescence. Ku70 deficiency leads to growth retardation. Reduced Ku80 protein levels in Ku-70 deficient mice. Early senescence of Ku70-deficient cells. "Leaky" T cell development. Increased incidence of thymic tumors in Ku70-deficient mice. Early arrest of B cell development in Ku70-deficient mice. Ku70 null cells display inefficient V(D)J recombination in vitro. Ku70-deficient mice have abnormal TCR V(D)J recombination in vivo.
Genetic Information
Gene Name	Thyroid autoantigen 70kDa, Ku antigen
Gene Symbol	G22P1
Reference Sequence	n/a
MGI Gene Record	n/a
LocusLink	n/a
Disease	n/a
OMIM	n/a
Gene Models	n/a
Biopathways	n/a
Gene Ontology
Molecular Function	n/a
Biological Process	n/a
Cellular Component	n/a
Publications
Title	Gu Y, Seidl KJ, Rathburn GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, and Alt FW.. Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice..  Immunity (1997) Nov;7(5):653-65.

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Last Reviewed: 21 August 2007