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Model Detail

   
Mouse Model Information
Model Name PRKR
Investigator Warren Ladiges
Status available
Availability MMRRC
Strain C57BL/6J (Black 6)
Species of Origin Human
Mutation Type Point Mutant
Manipulation Type transgenic
Conditional N
Projected Use Apoptosis and cell cyce regulation associated with interferon senstivity
Phenotype Summary Spleen cells from transgenic mice are resistant to apoptosis when treatred with the genotoxic agent actinomycin D, and show a decrease in proliferation in response to Con A.
Genetic Information
Gene Name protein kinase, interferon-inducible double stranded RNA dependent
Gene Symbol PRKR
Reference Sequence n/a
MGI Gene Record n/a
LocusLink n/a
Disease n/a
OMIM n/a
Gene Models n/a
Biopathways n/a
Gene Ontology
Molecular Function n/a
Biological Process n/a
Cellular Component n/a
Publications
Title Ladiges WC, Morton J, Hopkins H, Wilson R, Filley G, Ware C, Gale M.. Expression of human PKR protein kinase in transgenic mice. J Interferon and Cytokine Res 22:329-334, 2002 Exiting the NIEHS site
   
USA.gov Department of Health & Human Services National Institutes of Health
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Last Reviewed: 21 August 2007