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Selected Publications

Comparative Genomics Group

  1. Schwartz, D.A., Freedman, J.H., and Linney, E.A. (2004) Environmental Genomics: A key to understanding biology, pathophysiology, and disease. Hum. Mol. Gen. 13, R217-224.  [Abstract] ( Exit NIEHS
  2. Mattie, M.D., and Freedman, J.H. (2004) Copper-inducible transcription: Regulation by metal- and oxidative stress-responsive pathways. Am. J.Physiol. Cell. Physiol. 286, C293-C301.
  3. Dong, J. Song, M.O., Freedman, J.H. (2005) Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1 Biochim. Biophys. Acta - Gene Struct. Expression. 1727, 16-26.
  4. Members of the Toxicogenomics Research Consortium (2005) Toxicogenomics Research Consortium: Standardizing global gene analysis between laboratories and across platforms. Nat. Methods 2, 351-356.
  5. Song, M.O and Freedman, J.H. (2005) Expression of copper-responsive genes in HepG2 cells. Molec. Cell Biochem. 279, 141-147.
  6. Levin, E.D., Perraut, C., Pollard, N., and Freedman, J.H. (2006) Metallothionein expression and neurocognitive function in mice. Phsyiol Behavio. 87, 513-518.  [Abstract] ( Exit NIEHS
  7. Meyer, J.N., Boyd, W.A., Azzam, G.A., Haugen, A.C., Freedman, J.H., and Van Houten, B. (2007) Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. Genome Biol. 8, R70.
  8. Cui, Y., McBride, S.J., Boyd, W.A., Alper, S., and Freedman, J.H. (2007) Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity. Genome Biol. 8, R122.
  9. Boyd, W.A., McBride, and Freedman, J.H. (2007) Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: Evaluation of a novel, high-throughput screening assay. PLoS One. 12, e1259.
  10. Dong, J., Boyd, W., and Freedman, J.H. (2008) Molecular characterization of two homologs of the Caenorhabditis elegans cadmium-responsive gene cdr-1: cdr-4 and cdr-6. J. Mol. Biol. 376, 621-633.
  11. Eddins, D., Petro, A., Pollard, N., Levin, E.D., and Freedman, J.H. (2008) Mercury-induced cognitive impairment in metallothionein-1/2 null mice. Neurotoxicol. Teratol. 30, 88-95.
  12. Jin, Y.h., Dunlap, P., Al-Refai1, H., McBride, S.J., Bushel, P. and Freedman, J.H. (2008) Global transcriptome and deletome profiles of yeast exposed to transition metals. PLoS Genet. 4, e1000053.
  13. Mattie, M.D., McElwee, M., and Freedman, J.H. (2008) Mechanism of copper-activated transcription: Activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J. Mol. Biol. 383, 1008-1018. Department of Health & Human Services National Institutes of Health
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