Anti-HIV Drugs in Development

	Please click on the column heading to sort alphabetically. The reset button will restore the table where the traditional Drug Classes are listed first. For structures (if available) and chemical/biological data in NIAID's HIV/OI Therapeutics Database please click on the Aids Number cited for the drug.
RESET	DRUG_CLASS (TARGET) ANTI-HIV_DRUG ALTERNATE NAMES DRUG_STATUS AIDS_NUMBER NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  ALOVUDINE  MIV-310; FLT  PHASE II  000008 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  BETA-FLUORO-DDA  LODENOSINE; FDDA  PHASE II  000011 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  MIV-210  3'-FddG; FddGuo; FLG; GSK204937  PHASE I/II  000025 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DEXELVUCITABINE  REVERSET; DFC; D-D4FC; BETA-D-D4FC; 5F-D4C; DPC 817  PHASE II  000572 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  BEA-005    PRECLINICAL  000900 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  BETA-D-FD4C    PRECLINICAL  001231 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  PHOSPHAZID  AZT-HP; NICAVIR  PRECLINICAL  001492 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DIOXOLANE THYMIDINE  DOT  PHASE I  004279 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  (+)-.BETA.-D-FDOC  (+)-5F-DIOXOLANE-C; (+)-FDOC; D-FDOC  PRECLINICAL  004548 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  RACIVIR  PSI 5004  PHASE I/II  005245 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  AMDOXOVIR  DAPD  PHASE II  005431 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  EMIVIRINE  COACTINON; MKC 442  PHASE III  005650 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  LOBUCAVIR  CYGALOVIR; BMS180194  PHASE I  030961 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DTTP  TTP; 5'-TTP  PRECLINICAL  031903 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  COMPOUND X    PRECLINICAL  043398 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  AVX754  SPD754; (-)dOTC; BCH-10618  PHASE II  058066 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  ELVUCITABINE  ACH-126,443; BETA-L-FD4C; FD4C  PHASE II  060327 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  STAMPIDINE  HI-113  PRECLINICAL  060404 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  SPD756  BCH-13520  PHASE I  107981 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  4'-ETHYNYL D4T  4-ED4T  PRECLINICAL  209894 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  KP-1461  KP-1212  PHASE I  293211 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  CALANOLIDE A     PHASE II  004462 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  L-737,126;  CSIC; RS1202  PRECLINICAL  005228 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  HI-236  D-PBT; DDE236  PRECLINICAL  007227 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  GW420867  HBY1293  PHASE II  008293 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  UC781    PRECLINICAL  029940 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  PNU-142721    PRECLINICAL  057913 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  CAPRAVIRINE  AG-1549; S-1153  PHASE II  058025 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  RD4-2217    PRECLINICAL  058224 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DPC 961    PHASE II  081734 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DPC 083  BMS-561390; AI-183; DPC-083  PHASE II  081735 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DPC-963    PHASE I  081736 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  SJ-3366    PRECLINICAL  082419 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  ETRAVIRINE  TMC 125; R165335  PHASE III  105156 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  DAPIVIRINE  TMC 120; R147681  PHASE II  105293 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  GW678248    PHASE II  108658 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  NSC678248     PHASE I  147869 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  GSK695634    PHASE II  152302 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR  BILR 355 BS  BILR 355  PHASE I  212773 NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITOR  ADEFOVIR DIPIVOXIL  PREVEON; HEPSERA; Bis(POM)-PMEA; GS-840  PHASE II/III  028595 NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITOR  GS-7340    PHASE I  046774 PYROPHOSPHATE REVERSE TRANSCRIPTASE INHIBITOR  B-PFA  ODG-PFA; OCTADECYL-G-PFA  PRECLINICAL  084951 PYROPHOSPHATE REVERSE TRANSCRIPTASE INHIBITOR  EB-PFA  ETHYL-BATYL-PFA  PRECLINICAL  084954 NUCLEOTIDE COMPETING REVERSE TRANSCRIPTASE INHIBITOR  RILPIVIRINE  TMC-278; R278474  PHASE I/II  169030 PROTEASE INHIBITOR  PD-178390  CI-1029  PHASE I  001438 PROTEASE INHIBITOR  DMP323  XM323  PHASE I  005340 PROTEASE INHIBITOR  DPC-681    PHASE I  007467 PROTEASE INHIBITOR  MOZENAVIR  DMP-450  PHASE II  028412 PROTEASE INHIBITOR  LB-71350    PRECLINICAL  031415 PROTEASE INHIBITOR  DPC-684    PHASE I  041322 PROTEASE INHIBITOR  AG-1776  KNI-764; JE-2147  PRECLINICAL  070938 PROTEASE INHIBITOR  DARUNAVIR  TMC 114; UIC-96017  PHASE III  073035 PROTEASE INHIBITOR  TMC 126  UIC-94003  PHASE I  073036 PROTEASE INHIBITOR  L-756,423  MK-944A  PHASE II  085909 PROTEASE INHIBITOR  DOXOVIR-TOPICAL  CTC-96  PHASE I  121847 PROTEASE INHIBITOR  BRECANAVIR  VX-385; GW0385; GSK640385; BCV  PHASE II  223868 PROTEASE INHIBITOR  UIC02031    PRECLINICAL  228403 ATTACHMENT INHIBITOR  BMS-488043  BMS-043  PHASE I/II  171276 ENTRY INHIBITOR (GP120)  PEPTIDE T    PHASE II  000530 ENTRY INHIBITOR  R15K  BLOCKAIDE/CR  PHASE I  005445 ENTRY INHIBITOR (CCR5)  NNY-RANTES    PRECLINICAL  008372 ENTRY INHIBITOR (CCR5/CXCR4 CO-RECEPTOR)  AMD8664    PRECLINICAL  009877 ENTRY INHIBITOR (CCR5)  SCH-C  SCH 351125; AK671/SCH-C; SC-351125  PHASE II  021039 ENTRY INHIBITOR (CXCR4)  AMD-3100  JM3100; SID791; JM2987  PHASE III  025303 ENTRY INHIBITOR (CCR5/CXCR4 CO-RECEPTOR)  ALX40-4C    PHASE I  029803 ENTRY INHIBITOR (CCR5/CXCR4 CO-RECEPTOR)  NSC651016    PHASE I  030697 ENTRY INHIBITOR (CCR5)  IC9564    PRECLINICAL  033640 ENTRY INHIBITOR (CCR5/CXCR4 CO-RECEPTOR)  AMD3465    PRECLINICAL  038376 ENTRY INHIBITOR (CCR5)  APLAVIROC  ONO4128; GW-873140; AK602; GSK-873,140  PHASE III  043673 ENTRY INHIBITOR  CYANOVIRIN N    PRECLINICAL  045707 ENTRY INHIBITOR (CCR5/CXCR4 CO-RECEPTOR)  AOP-RANTES    PRECLINICAL  051981 ENTRY INHIBITOR (CD4)  PRO 542  CD4-IgG2  PHASE II  072622 ENTRY INHIBITOR (CCR5)  TAK-779    PHASE I  081429 ENTRY INHIBITOR (CCR5)  PRO 140    PHASE I/II  088103 ENTRY INHIBITOR  DEXTRIN 2-SULPHATE  VIRALDON; EMMELLE; D2S  PHASE I  095042 ENTRY INHIBITOR  RETROCYCLIN-1    PRECLINICAL  104238 ENTRY INHIBITOR (CCR5)  MARAVIROC  UK-427,857  PHASE II/III  104834 ENTRY INHIBITOR (GP120)  NSC13778    PRECLINICAL  159858 ENTRY INHIBITOR (CCR5/CXCR4 CO-RECEPTOR)  AMD3451    PRECLINICAL  166138 ENTRY INHIBITOR (GP120)  BMS378806  BM806  PHASE I  171241 ENTRY INHIBITOR (CD4)  TNX-355  Hu5A8  PHASE II  209859 ENTRY INHIBITOR (CCR5)  VICRIVIROC  SCH-D; SCH 417690; SCH-417  PHASE III  210504 ENTRY INHIBITOR (CCR5)  TAK-652    PRECLINICAL  224423 VIRAL FUSION INHIBITOR (GP41 )  T-649    PRECLINICAL  006554 VIRAL FUSION INHIBITOR (GP41 )  5-HELIX    PRECLINICAL  059335 VIRAL FUSION INHIBITOR  DP-178    PRECLINICAL  059486 VIRAL FUSION INHIBITOR (GP41)  T-1249    PHASE II  108212 VIRAL FUSION INHIBITOR (GP41 )  NB-2    PRECLINICAL  215772 VIRAL FUSION INHIBITOR (GP41 )  NB-64    PRECLINICAL  215773 INTEGRASE INHIBITOR  L-870810  L-000870810  PHASE I  013884 INTEGRASE INHIBITOR  DICAFFEOYLQUINIC ACID  3,5-DCQA  PRECLINICAL  028062 INTEGRASE INHIBITOR  DICAFFEOYLTARTARIC ACID    PRECLINICAL  029768 INTEGRASE INHIBITOR  ZINTERVIR  AR177; T30177; DBM-2245  PHASE I  032936 INTEGRASE INHIBITOR  GSK:S-1360  S-1360, GW810781  PHASE II  035995 INTEGRASE INHIBITOR  INDOLICIDIN    PRECLINICAL  085037 INTEGRASE INHIBITOR  L-731,988    PRECLINICAL  086031 INTEGRASE INHIBITOR  L-708,906    PRECLINICAL  086032 INTEGRASE INHIBITOR  ITI-367    PRECLINICAL  342593 IMMUNOMODULATOR  AMPLIGEN  ATVOGEN  PHASE II  000136 IMMUNOMODULATOR  INTERLEUKIN-2  IL-2; ALDESLEUKIN; PROLEUKIN  PHASE II  001802 IMMUNOMODULATOR  WF10  TCDO; OXOFERIN  PHASE III  004703 IMMUNOMODULATOR  PROCAINE HCL  ANTICORT  PHASE II  019136 MATURATION INHIBITOR  CHLOROQUININE  CHLOROQUINE  PRECLINICAL  000733 MATURATION INHIBITOR  PA-457    PHASE II  028530 ANTI-SENSE  GEM-91    PHASE I  029878 CELLULAR INHIBITOR (RIBONUCLEOTIDE REDUCTASE)  HYDROXYCARBAMIDE  DROXIA; HU; HYDREA; HYDROXYUREA  PHASE II/III  006310 CELLULAR INHIBITOR (RIBONUCLEOTIDE REDUCTASE)  RESVERETOL    PHASE I  025474 CELLULAR INHIBITOR  MYCOPHENOLATE MOFETIL  RS-61443; MMF; CELLCEPT  PHASE I/II  059828 CELLULAR INHIBITOR (PHOSPHORYLATION ENHANCER)  DIDOX    PRECLINICAL  088319 ZINC FINGER INHIBITOR  CI-1012    PHASE I  010943 ZINC FINGER INHIBITOR  AZODICARBONAMIDE  ADA  PHASE II  029805 ZINC FINGER INHIBITOR (GP120 V3 LOOP BINDERS)  FP-21399    PRECLINICAL  061016 CAPSID INHIBITOR (P24)  GPG-NH2    PHASE II  008321 GLCOCORTICOID INHIBITOR  MIFEPRISTONE  RU-486; RU486  PHASE I  025200 TAT INHIBITOR  CURCUMIN  DIFERULOYLMETHANE  PRECLINICAL  040146 GLUCOSE-6-PHOSPHATE DEHYDROGENASE INHIBITOR  IMMUNITIN  HE2000; INACTIVIN; ALPHA-EPIBROMIDE  PHASE II  060007 REV INHIBITOR  CNI-1493  AXD455; SEMAPIMOD  PRECLINICAL  121302 OTHER  POLYACRYLIC ACID    PRECLINICAL  122601 MAP KINASE INHIBITOR (P38 INHIBITOR)  RWJ67567    PRECLINICAL  209034 ATM KINASE INHIBITOR  KU-55933    PRECLINICAL  284437	Some useful sites where additional information on these drugs may be found: