Agent Name |
Phenylhydrazine |
CAS Number |
100-63-0 |
Formula |
C6-H8-N2 |
Major Category |
Nitrogen Compounds |
Synonyms |
Fenilidrazina [Italian]; Fenylhydrazine [Dutch]; Hydrazine, phenyl-; Hydrazine-benzene; Hydrazinobenzene; Hydrazobenzene; Monophenylhydrazine; Phenylhydrazin [German]; Phenylhydrazine; [ChemIDplus] UN2572 |
Category |
Hydrazines |
Description |
Colorless to pale-yellow liquid or solid (below 67 degrees F) with a faint, aromatic odor; [NIOSH] |
Sources/Uses |
Used in the synthesis of dyes and pharmaceuticals; [ACGIH] |
Comments |
Hemolytic anemia has been observed in workers after inhalation and dermal exposures. [ACGIH] Phenylhydrazine is a potent skin sensitizer and can cause hemolytic anemia by all routes of exposure. Toxic effects were observed in patients treated for polycythemia with doses of 0.2 G/day for 3 or 4 doses, then 0.1 G/day. Adverse effects included hemolytic anemia, liver injury, and methemoglobinemia. [HSDB] Can cause hemolytic anemia and skin sensitization; [ICSC] Causes first-degree burns on short exposure and second-degree burns on prolonged exposure; [CHRIS] |
Exposure Assessment |
Skin Designation (ACGIH) |
Yes |
TLV (ACGIH) |
0.1 ppm |
PEL (OSHA) |
5 ppm |
IDLH (NIOSH) |
15 ppm |
Excerpts from Documentation for IDLHs |
No data on acute or chronic inhalation toxicity are available on which to base the IDLH. Systemic effects described by Patty [1963] were caused by chronic exposures from oral dosing. NIOSH [1976] cited a rat oral LD50 of 188 mg/kg [Ekshtat 1965] which provides a calculated estimate of 1,300 mg/m3 (295 ppm) for the IDLH. |
Vapor Pressure |
0.02 mm Hg |
Lethal Concentration |
LC50 (rats) = 2,610 mg/m3 |
Explanatory Notes |
Flash point = 88 deg C; |
Flammability (NFPA) |
2: high ambient temperature required |
Adverse Effects |
Methemoglobinemia |
Methemoglobinemia, Secondary |
Anemia |
Anemia, Hemolytic |
Dermatotoxin |
Skin Burns |
Skin Sensitizer |
Yes |
Hepatotoxin |
Hepatotoxin, Secondary |
Links to Other NLM Databases |
Health Studies |
Human Health Effects from Hazardous Substances Data Bank: PHENYLHYDRAZINE
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