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Office of Technology Transfer and Development

Clinical Trials

NHLBI is well positioned to both conduct and participate in clinical trials. Many of the physicians here are recognized experts and have conducted trials both nationally and internationally. Our Scientists have extensive experience in developing, conducting and monitoring clinical trials. The NHLBI Office of Technology Transfer and Development (OTTAD) also serves as a Technology Transfer Service Center for the National Center for Research Resources (NCRR), the National Institute of Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Environmental Health Sciences (NIEHS), and the National Institute of Nursing Research (NINR) and can facilitate collaborative Clinical Trials at these institutes. Please Contact our office for additional information. For more information on the Clinical Trials listed below as well as other NIH trials go to http://clinicalstudies.info.nih.gov/.

Recent Clinical Trials at NHLBI

NHLBI FY 2004 Intramural Projects - By Principal Investigator

Project #

Title

 

Adelstein, Robert S.

 

Laboratory of Molecular Cardiology

HL004216

Function of Nonmuscle Myosin II Heavy Chains

 

HL004218

In Vivo Function of Nonmuscle Myosin II-A

 

HL004223

Role of Nonmuscle Myosins in Cardiac Development

 

HL004228

Role of Nonmuscle Myosin II-B in Brain Development

 

HL004230

Nonmuscle Myosin II-C and its Isoform

 

HL004235

Identification of Downstream Signals for Pitx2a

 

HL004236

Alternative Splicing of Nonmuscle Myosin Heavy Chains

 

Arai, Andrew E.

 

Laboratory of Cardiac Energetics

HL004607

MRI Evaluation of Acute Cardiovascular Disease

 

Balaban, Robert S.

 

Laboratory of Cardiac Energetics

HL004601

Control of Cellular Energy Metabolism

 

Barrett, Austin John.

 

Hematology Branch

HL002342

Graft-Versus-Leukemia

 

Beaven, Michael A.

 

Laboratory of Molecular Immunology

HL000990

Generation of Cytokines and Arachidonic Acid in Mast Cells

 

HL000993

Secretion of Granules from Mast Cells

 

Boehm, Manfred

 

Cardiovascular Branch

HL005066

Stem Cell Biology in Cardiovascular Regeneration

 

Brooks, Bernard R.

 

Laboratory of Biophysical Chemistry

HL001050

Molecular Dynamics Simulations of Biological Macromolecules

 

HL001051

Development of Theoretical Methods for Studying Biological Macromolecules

 

HL001052

Development of Advanced Computer Hardware and Software

 

Brown, Kevin E.

 

Hematology Branch

HL002319

Viruses and Hematopoeiesis

 

Burg, Maurice Benjamin

 

Laboratory of Kidney and Electrolyte Metabolism

HL001283

Response of Renal Cells to Osmotic Stress

 

Cannon, Richard O.

 

Cardiovascular Branch

HL005059

G-CSF Mobilizes Endothelial Progenitor Cells in Coronary Artery Disease Patients

 

HL005063

Nitrite as a Source of Bioactive Nitric Oxide

 

HL005064

Outcomes and Risks of G-CSF Administration to CAD Patients

 

HL005065

Endothelial Progenitor Cells and Endothelial Function During Cardiac Rehabilitation

 

Childs, Richard W.

 

Hematology Branch

HL002345

Allogeneic Immunotherapy

 

Chock, P. Boon.

 

Laboratory of Biochemistry

HL000202

Kinetics, Regulation, and Mechanisms of Biochemical Reactions

 

Chung, Jay H.

 

Laboratory of Biochemical Genetics

HL002243

DNA Damage Response in Eukaryotic Cells

 

Daniels, Mathew

 

Laboratory of Cell Biology

HL000158

Mechanisms of Central Nervous System Neuron Development

 

Donaldson, Julie G.

 

Laboratory of Cell Biology

HL000517

Cellular Function of the ADP-ribosylation Factor 6 (Arf6) GTP Binding Protein

 

Dunbar, Cynthia E.

 

Hematology Branch

HL002339

Gene Transfer and Ex Vivo Manipulation of Hematopoietic Cells

 

Eisenberg, Evan

 

Laboratory of Cell Biology

HL000516

70-kda Heat Shock Proteins and their Associated Cofactors

 

Epstein, Neal D.

 

Laboratory of Molecular Cardiology

HL004996

Molecular Biology and Pathophysiology of Cardiomyopathy

 

HL005057

Adult Stem Cell Therapy for Cardiac Failure

 

Fales, Henry M.

 

Laboratory of Biophysical Chemistry

HL001003

Analysis of Peptides, Proteins, and Metabolites Using Mass Spectrometry

 

Ferretti, James

 

Laboratory of Biophysical Chemistry

HL001027

Three-dimensional Structures of Biological Macromolecules

 

Finkel, Toren

 

Cardiovascular Branch

HL005012

Reactive Oxygen Species As Mediators of Signal Transduction

 

Ginsburg, Ann

 

Laboratory of Biochemistry

HL000310

Protein Stability, Folding, Macromolecular Associations, and Ligand Binding

 

Gochuico, Bernadette R.

 

Pulmonary-Critical Care Medicine Branch

HL002543

Interstitial Lung Disease

 

Hammer, III, John A.

 

Laboratory of Cell Biology

HL000514

Structure and Function of Unconventional Myosins

 

Hendler, Richard W.

 

Laboratory of Cell Biology

HL000518

Mechanism of Energy Transduction by Bacteriorhodopsin

 

Huang, Charles

 

Laboratory of Biochemistry

HL000224

Viral Peptide as Antiviral Agent

 

Ito, Yoichiro

 

Laboratory of Biophysical Chemistry

HL001047

Centrifugal Precipitation Chromatography

 

HL001053

Development of Continuous Density Gradient Cell Separation Method

 

HL001054

Spiral Disk Assembly for High-Speed Countercurrent Chromatography

 

Kim, Yongsok

 

Laboratory of Molecular Cardiology

HL004224

Identifying Regulatory Genes Involved in Drosophila Heart Development By RNAi

 

Knepper, Mark A.

 

Laboratory of Kidney and Electrolyte Metabolism

HL001285

Solute and Water Transport in Renal Epithelia

 

Knutson, Jay R.

 

Laboratory of Biophysical Chemistry

HL001452

Time Resolved Fluorescence Spectroscopy

 

Kolobow, Theodor

 

Pulmonary-Critical Care Medicine Branch

HL001404

Ventilator-Associated Pneumonia. Bactericidal Tracheal Tubes. Mucus Shaver

 

Korn, Edward D.

 

Laboratory of Cell Biology

HL000506

Biochemical and Biological Properties of Myosins

 

Kotin, Robert M.

 

Laboratory of Biochemical Genetics

HL002231

Characterization of Adeno Associated Virus Non-structural Proteins

 

HL002237

Recombinant Adeno Associated Virus

 

Kruth, Howard S.

 

Cardiovascular Branch

HL002832

Mechanism of Cholesterol Accumulation in Human Atherosclerosis

 

Lederman, Robert J.

 

Cardiovascular Branch

HL005062

Biological and mechanical therapies enabled by cardiovascular interventional MRI

 

Leonard, Warren J.

 

Laboratory of Molecular Immunology

HL005401

Il-2 Receptors--Structure and Function

 

HL005402

Il-2 Receptors--Molecular Regulation

 

Levine, Rodney L.

 

Laboratory of Biochemistry

HL000225

Metal-Catalyzed Oxidation of Proteins

 

HL002544

Regulation of Cytokine-Mediated Airway Inflammation

 

Lo, Cecilia W.

 

Laboratory of Developmental Biology

HL005701

Cell-Cell Interactions and Cell Signaling in Cardiovascular Development

 

Manganiello, Vincent

 

Pulmonary-Critical Care Medicine Branch

HL002540

Expression, Structure/function and Regulation of Phosphodiesterase 3 Isoforms

 

HL002545

Phosphodiesterases as Therapeutic Targets: Translational Studies in Sarcoidosis

 

McVeigh, Elliot

 

Laboratory of Cardiac Energetics

HL004608

Ultra-Fast MRI for Cardiovascular Applications

 

HL004609

High Resolution Electromechanical Mapping of the Heart

 

Moss, Joel

 

Pulmonary-Critical Care Medicine Branch

HL000659

ADP-Ribosylation Cycles

 

HL002541

Characterization of the Pathogenesis of Lymphangioleiomyomatosis (LAM)

 

Nabel, Elizabeth G.

 

Cardiovascular Branch

HL005601

Molecular Genetics of Vascular Disease

 

Nirenberg, Marshall W.

 

Laboratory of Biochemical Genetics

HL000009

Cell Recognition and Synapse formation

 

Peterkofsky, Alan

 

Laboratory of Cell Biology

HL000151

The Biology of Sugar Transport in E Coli

 

Piszczek, Grzegorz

 

Laboratory of Biochemistry

HL000338

Calorimetric and Fluorescence Studies of Protein Properties and Interactions

 

Pohl, Lance

 

Laboratory of Molecular Immunology

HL000962

Mechanisms of Drug-Induced Toxicities

 

Raghuram, Viswanathan

 

Laboratory of Kidney and Electrolyte Metabolism

HL001286

Molecular Biology of Cystic Fibrosis

 

Rhee, Sue Goo.

 

Laboratory of Cell Signaling

HL005506

Hydrogen Peroxide as Intracellular Messenger

 

HL005509

Regulation of Phospholipase C Isozymes

 

Santamarina-Fojo, Silvia M.

 

Molecular Disease Branch

HL002058

Use of Animal Models to Study Lipid Genes that Modulate Atherosclerosis

 

Sellers, James R.

 

Laboratory of Molecular Cardiology

HL001786

Regulation of Smooth and Nonmuscle Myosin

 

HL004227

Structural and Functional Analysis of Drosophila Myosin V

 

HL004229

Studies of Myosin V

 

HL004231

Expression Studies of Myosin X

 

HL004232

Expression Studies of Other Unconventional Myosins

 

HL004234

Chemical Inhibitors of Myosin Function

 

Shamburek, Robert D.

 

Molecular Disease Branch

HL002064

Lipoprotein Metabolism in Genetic Dyslipoproteinemias

 

Stadtman, Thressa C.

 

Laboratory of Biochemistry

HL000205

Selenium Biochemistry

 

HL000211

Elucidation of Cellular Damage During Exposure to Oxidative Stress

 

Tjandra, Nico

 

Laboratory of Biophysical Chemistry

HL001048

NMR Studies of the Regulation of Cell Signaling

 

Vaughan, Martha

 

Pulmonary-Critical Care Medicine Branch

HL000627

Regulation of GTP-Binding Proteins

 

HL000656

Molecular and Biochemical Characterization of GTP-binding Proteins

 

Wen, Han

 

Laboratory of Cardiac Energetics

HL004606

Magnetic Resonance Imaging of Cardiac Function and Myocardial Tissue Properties

 

Young, Neal S.

 

Hematology Branch

HL002315

Pathogenesis and Treatment of Aplastic Anemia

 

Zhao, Keji

 

Laboratory of Molecular Immunology

HL005801

Genome-wide mapping of histone modifications

 

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