Selective Bibliography of Dr. Laurence H. Hurley
Howard J. Schaeffer Professor of Pharmaceutical Sciences
Professor of Medicinal Chemistry
Professor of Chemistry
Professor BIO5 Institute for Collaborative Research
Department of Chemistry
Arizona Cancer Center, University of Arizona

"G-quadruplexes: A New Receptor Class for Drug Targeting"
Wednesday, March 5, 2008

1. Palumbo SL, Memmott RM, Uribe DJ, Krotova-Khan Y, Hurley LH, Ebbinghaus SW
A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity
NUCLEIC ACIDS RESEARCH [Epub ahead of print] Feb 11 2008

2. Cashman DJ, Buscaglia R, Freyer MW, Dettler J, Hurley LH, Lewis EA
Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element
JOURNAL OF MOLECULAR MODELING 14 (2):93-101 Feb 2008

3. Guo K, Pourpak A, Beetz-Rogers K, Gokhale V, Sun D, Hurley LH
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129 (33):10220-10228 Aug 22 2007

4. Zhu M, Gokhale VM, Szabo L, Munoz RM, Baek H, Bashyam S, Hurley LH, Von Hoff DD, Han H
Identification of a novel inhibitor of urokinase-type plasminogen activator
MOLECULAR CANCER THERAPEUTICS 6 (4):1348-1356 Apr 2007

5. Freyer MW, Buscaglia R, Kaplan K, Cashman D, Hurley LH, Lewis EA
Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin
BIOPHYSICAL JOURNAL 92 (6):2007-2015 Mar 15 2007

6. Qin Y, Rezler EM, Gokhale V, Sun D, Hurley LH
Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4
NUCLEIC ACIDS RESEARCH 35 (22):7698-7713 2007

7. Hahn T, Szabo L, Gold M, Ramanathapuram L, Hurley LH, Akporiaye ET
Dietary administration of the proapoptotic vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer
CANCER RESEARCH 66 (19):9374-9378 Oct 1 2006

8. Warner SL, Munoz RM, Stafford P, Koller E, Hurley LH, Von Hoff DD, Han H
Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells
MOLECULAR CANCER THERAPEUTICS 5 (10):2450-2458 Oct 2006

9. Warner SL, Bashyam S, Vankayalapati H, Bearss DJ, Han H, Mahadevan D, Von Hoff DD, Hurley LH
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach
MOLECULAR CANCER THERAPEUTICS 5 (7):1764-1773 Jul 2006

10. Dai J, Chen D, Jones RA, Hurley LH, Yang D
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
NUCLEIC ACIDS RESEARCH 34 (18):5133-5144 2006

Created 02/21/08