Testing Status of Agents at NTP
Acetonitrile
CASRN: 75-05-8
Formula: C2 H3 N
Synonyms/Common Names:
- METHYL CYANIDE
Known Uses:
SOLVENT IN HYDROCARBON EXTRACTION PROCESSES. SPECIALTY SOLVENT. CHEMICAL INTERMEDIATE. SEPARATION OF FATTY ACIDS FROM VEGETABLE OILS. PHARMACEUTICALS. (TDB)
Short-Term Toxicity
- 14-Day (Inhalation)
(C60822A) Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Inhalation)
(C60822A) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0,25,400 PPM/10 PER GROUP
- 13-WEEK (Inhalation)
(C60822B) Completed
- NTIS No. PB96-214937
(Peer Review 06/21/1994)
Citation: Toxicology and Carcinogenesis Studies of Acetonitrile (CAS No. 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 100, 200, 400, 800, OR 1600 PPM (10/S/S)
- NTIS No. PB96-214937
(Peer Review 06/21/1994)
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C60822B) Report Complete
- TR-447 (NTIS No. PB96-214937)
(Peer Review 06/21/1994)
Toxicology and Carcinogenesis Studies of Acetonitrile (CAS No. 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 100, 200, OR 400 PPM M: 0, 50, 100, OR 200 PPM ; 50/GROUP
- TR-447 (NTIS No. PB96-214937)
(Peer Review 06/21/1994)
Special Studies
- Mechanisms
(S0499) Completed
- Citation: GHANAYEM, ET.AL., STUDIES ON THE MECHANISM OF ACETONITRILE TOXICITY I: WHOLE BODY AUTORADIOGRAPHIC DISTRIBUTION & MACROMOLECULAR INTERACTION OF 2-14C-ACETONITRILE IN MICE, PHARM & TOXICOL 70:322-330, 1992
- M Mice
- Dose: 60 UMOL/KG
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(119279) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Inconclusive
- Sister Chromatid Exchange Weakly Positive
- Micronucleus
(A41659) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Female Negative
- Salmonella
(571879) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella
(831005) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- Conventional Teratology (Inhalation)
(TER91039) Completed
- Citation: DE94008272
- F Rats: Sprague Dawley
- Rats Maternal ?
- Rats Fetal Negative
- Dose: 0, 100, 400, 1200 PPM 6 HR/DAY, 7 DAYS/WEEK
Web page last updated on January 22, 2009