National Toxicology Program

CASRN: 119-84-6

Formula: C9-H8-O2

Synonyms/Common Names:

• 3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE (9CI)

Known Uses:

FRAGRANCE IN COSMETICS AND DETERGENTS. FLAVORING AGENT IN FOODS AND BEVERAGES. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C55890A) Completed 
  • NTIS No. PB95-103925
    Citation: Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55890A) Completed 
  • NTIS No. PB95-103925
    Citation: Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,75,1200, M: 0,100,1600 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C55890B) Report Complete 
  • TR-423 (NTIS No. PB95-103925)  (Peer Review 06/23/1992)
    Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice Some Evidence 
  • Dose: R: 0,150,300,600, M: 0,200,400,800 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (733791) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Micronucleus  (A43806) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (911172) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative