National Toxicology Program

Selected information from two of the National Library of Medicine's databases: ChemIDPlus¹ and HSDB².

Names (NTP)

• 3'-Azido-3'-deoxythymidine (AIDS)
• AZT (AIDS INITIATIVE)
• AZT TRANSPLACENTAL CARCINOGENESIS STUDY (AIDS INITIATIVE)
• ZIDOVUDINE
• 3'-AZIDO-3'-DEOXYTHYMIDINE
• RETROVIR
• AZIDOTYMIDINE
• AZT transplacental carcinogenesis study

Structure

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Chemical Properties²

Property	Description
Color/Form	White to beige, crystalline solid Needles from petroleum ether
Odor	Odorless
Taste	None found
Boiling Point	None found
Melting Point	106-112 deg C
Molecular Weight	267.24
Corrosivity	None found
Critical Temperature & Pressure	None found
Density/Specific Gravity	None found
Disassociation Constants	None found
Heat of Combustion	None found
Heat of Vaporization	None found
log P (octanol-water)	log Kow = 0.05
pH	None found
Solubilities	71 mg/ml in alc @ 25 deg C In water, 20,000 mg/l @ 25 deg C
Spectral Properties	UV max in water = 226 nm (epsilon=11,650)
Surface Tension	None found
Vapor Density	None found
Vapor Pressure	5.2X10-20 mm Hg @ 25 deg C /Estimated/
Relative Evaporation Rate	None found
Viscosity	None found
Other Properties	Zidovudine is a thymidine analog which differs structurally from thymidine in that zidovudine contains a 3'-azide group rather than a 3'-hydroxyl group. Henry's Law constant = 2.0X10-22 atm-cu m/mol @ 25 deg C /Estimated/ Hydroxyl radical reaction rate constant = 7.7X10-11 cu cm/molec-sec @ 25 deg C /Estimated/

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Uses²

• MEDICATION **PEER REVIEWED**
  
• Antiviral
  

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Superlist Classes¹

• Overall Carcinogenic Evaluation: 2B
  

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Notes (Sources: NTP,HSDB,RTECS,MESH)¹

• None found

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Other Registry Numbers¹

• 399024-19-2
  

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)¹

• 3'-Azido-3'-deoxythymidine
• Azidothymidine
• AZT
• BW-A 509U
• HSDB 6515
• Retrovir
• Zidovudine

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Links to Additional Information¹

• AIDSinfo
• CCRIS
• ClinicalTrials.gov
• DailyMed
• DART
• DrugPortal
• EMIC
• HSDB
• MedlinePlusAll
• MedlinePlusDrug
• MeSH Heading
• MeSH
• PubChem
• PubMed AIDS
• PubMed Cancer
• PubMed Toxicology
• PubMed
• TOXLINE

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Footnotes

¹ Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

² Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.