Testing Status of Agents at NTP
1-Phenyl-3-methyl-5-pyrazolone
CASRN: 89-25-8
Formula: C10-H10-N2-0
Synonyms/Common Names:
- 2,4-DIHYDRO-5-METHYL-2-PHENYL-3H-PYRAZOL-3-ONE (9CI)
Known Uses:
INTERMEDIATE FOR DYES AND DRUGS; LAB REAGENT
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03952) Completed
- NTIS No. PB287122
(Peer Review 06/29/1978)
Citation: Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CAS No. 89-25-8) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB287122
(Peer Review 06/29/1978)
- 13-Week (Dosed-Feed)
(C03952) Completed
- NTIS No. PB287122
(Peer Review 06/29/1978)
Citation: Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CAS No. 89-25-8) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,2150,21600, M: 0,2160,31600 PPM/10 PER GROUP
- NTIS No. PB287122
(Peer Review 06/29/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03952) Report Complete
- TR-141 (NTIS No. PB287122)
(Peer Review 06/29/1978)
Bioassay of 1-Phenyl-3-methyl-5-pyrazolone for Possible Carcinogenicity (CAS No. 89-25-8) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,2500,5000, M: 0,7500,15000 PPM/50 PER GROUP
- TR-141 (NTIS No. PB287122)
(Peer Review 06/29/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(837716) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Mouse Lymphoma
(216441) Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Positive
- Salmonella (NCI)
(N-9242) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(711054) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
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