Testing Status of Agents at NTP
C.I. Acid red 114
CASRN: 6459-94-5
Formula: C37-H30-N4-O10-S3.2NA
Synonyms/Common Names:
- 8-((3,3'-DIMETHYL-4'-((4-(((4-METHYLPHENYL)SULFONYL)OXY)PHENYL)-AZO)(1,1'-BIPHENYL)-4-YL)AZO)-7-HYDROXY-1,3-NAPHTHALENEDISULFONIC ACID DISODIUM SALT
- RED 114, C.I. ACID
Known Uses:
DYE FOR SILK, JUTE FIBERS, WOOL, LEATHER. (TDB)
Short-Term Toxicity
- 14-Day (Dosed-Water)
(C61096) Completed
- NTIS No. PB92-189380
(Peer Review 03/11/1991)
Citation: Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies) - Rats: F344/N
- NTIS No. PB92-189380
(Peer Review 03/11/1991)
- 13-Week (Dosed-Water)
(C61096) Completed
- NTIS No. PB92-189380
(Peer Review 03/11/1991)
Citation: Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies) - Rats: F344/N
- Dose: 0, 600, 1200, 2500, 5000 PPM (10 PER GROUP)
- NTIS No. PB92-189380
(Peer Review 03/11/1991)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Water)
(C61096) Report Complete
- TR-405 (NTIS No. PB92-189380)
(Peer Review 03/11/1991)
Toxicology and Carcinogenesis Studies of C.I. Acid Red 114 (CAS No. 6459-94-5) in F344/N Rats (Drinking Water Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Dose: MR: 0,70,150,300, FR: 0,150,300,600 PPM(70,45,75,70 PER GROUP RESPECTIVELY)
- TR-405 (NTIS No. PB92-189380)
(Peer Review 03/11/1991)
Special Studies
- Metabolism (Gavage; Dosed-Feed)
(S0023) Completed
- Citation: LYNN, RK, DONIELSON, DW, ILIAS, AM, KENNISH, JM, WONG,K & MATTHEWS, HB: METABOLISM OF BISAZOBIPHENYL DYES DERIVED FROM BENZIDINE, 3,3'-DIMETHYLBENZIDINE OR 3,3'-DIMETHOXYBENZIDINE TO CARCINOGENIC AROMATIC AMINES IN THE DOG & RAT. TOXICOL APPL PHARMACOL, 56:248-258,1980.
- M Rats: Sprague Dawley; F Dog
- Dose: DOGS: 100 MG/KG; RATS: 100 MG/KG
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(226009) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Drosophila
(668235) Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Salmonella
(831184) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Positive
- Salmonella Reduction
(123112) Completed
- Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
- Positive
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