Summaries & Associations of Study Results
TR-527 Malachite Green Chloride and Leucomalachite Green
Target Organs and Levels of Evidence
NTP Technical Report Number 527
Produced from Chemtrack Database 05/14/04
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| LEUCOMALACHITE GREEN 129-73-7 |
02/17/04 | PLANT FUNGICIDE; STAINING BACTERIA; ANTISEPTIC; DYEING TEXTILES | Dosed-Feed R: 0, 91, 272, OR 543 PPM M: 0, 91, 204, OR 408 PPM | National Center for Toxicological Research |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: EQUIVOCAL EVIDENCE | THYROID GLAND: FOLLICULAR CELL ADENOMA OR CARCINOMA 0/47 2/47 1/48 3/46 | |||
| TESTES: INTERSTITIAL CELL ADENOMA 37/48 42/47 43/48 45/47 BILATERAL INTERSTITIAL CELL ADEMONA 22/48 30/47 38/48 39/47 | ||||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICLE CYST | |||
| LIVER: EOSINOPHILIC FOCUS; CYSTIC DEGENERATION | ||||
| OTHER CONSIDERATIONS: | MONONUCLEAR CELL LEUKEMIA: 29/48 16/47 19/48 7/47 | |||
| PITUITARY GLAND: ADENOMA 30/45 19/46 21/48 13/45 | ||||
| FR: EQUIVOCAL EVIDENCE | MAMMARY GLAND: ADEMONA OR CARCINOMA 0/48 2/48 3/48 4/48 | |||
| THYROID GLAND: FOLLICULAR CELL CARCINOMA OR ADENOMA 0/46 1/46 2/47 1/48 | ||||
| LIVER: HEPATOCELLULAR ADENOMA 1/48 3/48 0/48 3/48 | ||||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICLE CYST | |||
| LIVER: EOSINOPHILIC FOCUS; VACUOLIZATION CYTOPLASMIC | ||||
| OTHER CONSIDERATIONS: | MONONUCLEAR CELL LEUKEMIA: 17/48 8/48 5/48 8/48 | |||
| FM: SOME EVIDENCE | LIVER: ADENOMA OR CARCINOMA 3/47 6/48 6/47 11/47 | |||
| NON-NEOPLASTIC LESIONS: | URINARY BLADDER: INCLUSION BODY INTRACYTOPLASMIC | |||
| MALACHITE GREEN 569-64-2 |
02/17/04 | ANTIBACTERIAL AND ANTIFUNGAL AGENT, AS A DYE FOR CLOTH & LEATHER, AS AN HISTOLOGICAL STAIN, AS AN INTESTINAL ANTIHELMINTIC, AS A WOUND DISINFECTANT. CONSIDERED THE MOST EFFECTIVE AGENT FOR COMBATTING FUNGAL INFECTIONS IN AQUATIC SPECIES. | Dosed-Feed R: 0, 100, 300, OR 600 PPM M: 0, 100, 225, OR 450 PPM | National Center for Toxicological Research |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| FR: EQUIVOCAL EVIDENCE | THYROID GLAND: FOLLICULAR CELL ADENOMA OR CARCINOMA 0/46 0/48 3/47 2/46 | |||
| LIVER: ADENOMA 1/48 1/48 3/48 4/48 | ||||
| MAMMARY GLAND: CARCINOMA 2/48 2/48 1/48 5/48 | ||||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICLE CYST | |||
| LIVER: EOSINOPHILIC FOCUS | ||||
| OTHER CONSIDERATIONS: | MONONUCLEAR CELL LEUKEMIA: 19/48 17/48 10/48 1/48 | |||
| FM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | URINARY BLADDER: INCLUSION BODY CYTOPLASMIC | |||
| LIVER: INFILTRATION CELLULAR LYMPHOCYTE | ||||
Web page last updated on September 07, 2007
