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human anti-TGF-beta monoclonal antibody GC1008
A pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) -beta 1, 2 and 3 with potential antineoplastic activity. Human anti-TGF-beta monoclonal antibody GC1008 binds to and inhibits the activity of all isoforms of TGF-beta, whcih may result in the inhibition of tumor cell growth, angiogenesis, and migration. TGF-beta, a cytokine often over-expressed in various malignancies, may play an important role in promoting the growth, progression, and migration of tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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