Definition of etoposide phosphate - National Cancer Institute Drug Dictionary

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etoposide phosphate

A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. Check for or using this agent. ()

US brand name:		Etopophos

Abbreviation:		ETOP

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