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daniquidone A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of daniquidone is highly toxic and is capable of inducing unscheduled DNA synthesis; rapid acetylators are more likely to experience toxicity with this agent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081006042145im_/http://www.nci.nih.gov/images/spacer.gif) | batracylin | | ![](https://webarchive.library.unt.edu/eot2008/20081006042145im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081006042145im_/http://www.nci.nih.gov/images/spacer.gif) | 8-aminoisoindolo(1,2-b)quinazolin-12(10H)-one | | ![](https://webarchive.library.unt.edu/eot2008/20081006042145im_/http://www.nci.nih.gov/images/spacer.gif) |
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