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altretamine A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Hemel Hexaloids | | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Hexalen hexamethylmelamine | | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Hexastat Hexinawas | | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | HMM HXM | | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | ENT-50852 RB-1515 WR-95704 | | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20081005071608im_/http://www.nci.nih.gov/images/spacer.gif) | - 2,4,6-tris(dimethylamino)-s-triazine
- N,N,N',N',N",N"-hexamethyl-1,3,5-triazine-2,4,6-triamine
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