Testing Information

Testing Status of Agents at NTP

4-Chloro-m-phenylenediamine

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http://ntp.niehs.nih.gov/go/TS-10728-T

CASRN: 5131-60-2

Formula: C6 H7 CL N2

Synonyms/Common Names:

  • 4-CHLORO-1,3-BENZENEDIAMINE (9CI)

Known Uses:

DYE INTERMEDIATE

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03305) Completed 
    • NTIS No. PB285201  (Peer Review 04/26/1978)
      Citation: Bioassay of 4-Chloro-m-phenylenediamine for Possible Carcinogenicity (CAS No. 5131-60-2)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03305) Completed 
    • NTIS No. PB285201  (Peer Review 04/26/1978)
      Citation: Bioassay of 4-Chloro-m-phenylenediamine for Possible Carcinogenicity (CAS No. 5131-60-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,0.1,3.0, M: 0,0.03,3.0 %/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03305) Report Complete 
    • TR-085 (NTIS No. PB285201)  (Peer Review 04/26/1978)
      Bioassay of 4-Chloro-m-phenylenediamine for Possible Carcinogenicity (CAS No. 5131-60-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0,.2,.4, M: 0,.7,1.4 (AVG) %DIET/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (618847) Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Salmonella (NCI)  (N-9358) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (577801) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 

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Web page last updated on January 22, 2009