... |
Skip
navigation links ![Link to home page of HIV Drug Resistance Program website Link to home page of HIV Drug Resistance Program website](home_wht.gif)
![Link to Mission, HIV Drug Resistance Program, National Cancer Institute Link to Mission, HIV Drug Resistance Program, National Cancer Institute](mission_wht.gif)
![Link to Symposium on Antiviral Drug Resistance - external website Link to Symposium on Antiviral Drug Resistance - external website](symposium_wht.gif)
![Link to News & Events, HIV Drug Resistance Program, National Cancer Institute Link to News & Events, HIV Drug Resistance Program, National Cancer Institute](news_wht.gif)
![Link to Research Team, HIV Drug Resistance Program, National Cancer Institute Link to Research Team, HIV Drug Resistance Program, National Cancer Institute](research_blu.gif)
![Link to Clinical Trials, HIV Drug Resistance Program, National Cancer Institute Link to Clinical Trials, HIV Drug Resistance Program, National Cancer Institute](clinical_wht.gif)
![Link to Recruitment, HIV Drug Resistance Program, National Cancer Institute Link to Recruitment, HIV Drug Resistance Program, National Cancer Institute](recruit2_wht.gif)
![Link to Resources, HIV Drug Resistance Program, National Cancer Institute Link to Resources, HIV Drug Resistance Program, National Cancer Institute](resources_wht.gif)
![Link to Related Sites, HIV Drug Resistance Program, National Cancer Institute Link to Related Sites, HIV Drug Resistance Program, National Cancer Institute](related_wht.gif)
![Link to Staff Directory, HIV Drug Resistance Program, National Cancer Institute Link to Staff Directory, HIV Drug Resistance Program, National Cancer Institute](staff_wht.gif)
![](rule2.gif)
![Link to National Cancer Institute - external website Link to National Cancer Institute - external website](nci_wht.gif)
![Link to National Cancer Institute at Frederick - external website Link to National Cancer Institute at Frederick - external website](fcrdc_wht.gif) | ... |
Full
PubMed
List of Publications by F. Maldarelli Selected Publications
Morse, C.,
and Maldarelli, F. (2009) HIV infection. In
Strober, W., and Gottesman, S. (eds.), Immunology, Clinical Case Studies and Disease
Pathophysiology, John Wiley & Sons, in press. Kearney,
M., Maldarelli, F., Shao, W., Margolick, J.B., Daar, E.S., Mellors, J.W.,
Rao, V., Coffin, J.M., and Palmer, S. (2009) HIV-1 population genetics
and adaptation in newly infected individuals. J. Virol. , in press (Dec
30 Epub ahead of print). [Abstract] [Full-text
PDF
article - 293 K] Robertson,
S.M., Maldarelli, F., Natarajan, V., Formentini, E., Alfaro, R.M., and
Penzak, S.R. (2009) Efavirenz induces CYP2B6-mediated hydroxylation
of bupropion in healthy subjects. J. Acquir. Immune Defic. Syndr., in press
(Nov 4 Epub ahead of print). [Abstract] [Full-text
PDF
article - 119 K] Porter,
B.O., Anthony, K.B., Shen, J., Hahn, B., Keh, C.E., Maldarelli, F., Blackwelder,
W.C., Lane, H.C., Kovacs, J.A., Davey, R.T., and Sereti, I. (2009)
Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts
during HAART interruption: A randomized controlled trial. AIDS 23: 203-212. [Abstract] [Full-text
PDF
article - 252 K] Migueles,
S.A., Osborne, C.M., Royce, C., Compton, A.A., Joshi, R.P., Weeks, K.A., Rood,
J.E., Berkley, A.M., Sacha ,J.B., Cogliano-Shutta, N.A., Lloyd, M., Roby, G.,
Kwan, R., McLaughlin, M., Stallings, S., Rehm, C., O'Shea, M.A., Mican, J., Packard,
B.Z., Komoriya, A., Palmer, S., Wiegand, A.P., Maldarelli, F., Coffin,
J.M., Mellors, J.W., Hallahan, C.W., Follman, D.A., and Connors, M. (2008)
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination
associated with immune control. Immunity 29: 1009-1021. [Abstract] [Full-text
PDF
article - 1649 K] Ramanathan,
R., Pau, A.K., Busse, K.H., Zemskova, M., Nieman, L., Kwan, R., Hammer, J.H.,
Mican, J.M., and Maldarelli, F. (2008) Iatrogenic Cushing syndrome
after epidural triamcinolone injections in an HIV type 1-infected patient receiving
therapy with ritonavir-lopinavir. Clin. Infect. Dis. 47: e97-99. [Abstract] [Full-text
PDF
article - 109 K] Kutty,
G., Maldarelli, F., Achaz, G., and Kovacs, J.A. (2008) Variation
in the major surface glycoprotein genes in Pneumocystis jirovecii.
J. Infect. Dis. 198: 741-749. [Abstract] [Full-text
PDF
article - 523 K] Palmer,
S., Maldarelli, F., Wiegand, A., Bernstein, B., Hanna, G.J., Brun, S.C.,
Kempf, D.J., Mellors, J.W., Coffin, J.M., and King, M.S. (2008) Low-level
viremia persists for at least 7 years in patients on suppressive antiretroviral
therapy. Proc. Natl. Acad. Sci. USA 105: 3879-3884. [Abstract] [Full-text
PDF
article] Kearney,
M., Palmer, S., Maldarelli, F., Shao, W., Polis, M.A., Mican, J., Rock-Kress,
D., Margolick, J.B., Coffin, J.M., and Mellors, J.W. (2008) Frequent
polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase.
AIDS 22: 497-501. [Abstract] [Full-text
PDF
article] Ambrose,
Z., Palmer, S., Boltz, V.F., Kearney, M., Larsen, K., Polacino, P., Flanary, L.,
Oswald, K., Piatak, M., Jr., Smedley, J., Shao, W., Bischofberger, N., Maldarelli,
F., Kimata, J.T., Mellors, J.W., Hu, S.-L., Coffin, J.M., Lifson, J.D., and
KewalRamani, V.N. (2007) Suppression of viremia and evolution of human
immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral
therapy. J. Virol. 81: 12145-12155. [Abstract] [Full-text
PDF
article] Maldarelli,
F., Palmer, S., King, M.S., Wiegand, A., Polis, M.A., Mican, J., Kovacs, J.A.,
Davey, R.T., Rock-Kress, D., Dewar, R., Liu, S., Metcalf, J.A., Rehm, C., Brun,
S.C., Hanna, G.J., Kempf, D.J., Coffin, J.M., and Mellors, J.W. (2007)
ART suppresses plasma HIV- 1 RNA to a stable set point predicted by pretherapy
viremia. PLoS Pathog. 3: e46. [Abstract] [Full-text
PDF
article] Morse,
C., and Maldarelli, F. (2007) Enfuvirtide antiviral activity
despite rebound viremia and resistance mutations: Fitness tampering or a case
of persistent braking on entering? (Editorial Commentary). J. Infect. Dis.
195:318-321. [PubMed
citation] [Full-text PDF
article] Nikolenko,
G.N., Delviks-Frankenberry, K.A., Palmer, S., Maldarelli, F., Fivash, M.J.,
Jr., Coffin, J.M., and Pathak, V.K. (2007) Mutations in the connection
domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance.
Proc. Natl. Acad. Sci. USA 104: 317-322. [Abstract] [Full-text
PDF
article] Gafni,
R.I., Hazra, R., Reynolds, J.C., Maldarelli, F., Tullio, A.N., DeCarlo,
E., Worrell, C.J., Flaherty, J., Yale, K., Kearney, B.P., and Zeichner, S.L.
(2006) Tenofovir disoproxil fumarate and an optimized background regimen
of antiretroviral agents as salvage therapy: Impact on bone mineral density in
HIV-infected children. Pediatrics 118: 711-718. [Abstract] [Full-text
PDF
article]
Bashirova, A.A., Bleiber, G., Qi, Y., Hutcheson, H., Yamashita, T., Johnson, R.C.,
Cheng, J., Alter, G., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., May,
M., Maldarelli, F., Jacobson, L., O'Brien, S.J., Telenti, A., and Carrington,
M. (2006) Consistent effects of TSG101 genetic variability on multiple
outcomes of exposure to human immunodeficiency virus type 1. J. Virol. 80:
6757-6763. [Abstract] [Full-text
PDF
article] Palmer,
S., Boltz, V., Martinson, N., Maldarelli, F., Gray, G., McIntyre, J., Mellors,
J., Morris, L., and Coffin, J. (2006) Persistence of nevirapine-resistant
HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal
HIV-1 transmission. Proc. Natl. Acad. Sci. USA 103: 7094-7099. [Abstract] [Full-text
PDF
article] Palmer,
S., Boltz, V., Maldarelli, F., Kearney, M., Halvas, E.K., Rock, D., Falloon,
J., Davey, R.T., Jr., Dewar, R.L., Metcalf, J.A., Mellors, J.W., and Coffin, J.M.
(2006) Selection and persistence of non-nucleoside reverse transcriptase
inhibitor-resistant HIV-1 in patients starting and stopping non-nucleoside therapy.
AIDS 20: 701-710. [Abstract] [Full-text
PDF
article] Hazra,
R., Gafni, R.I., Maldarelli, F., Balis, F.M., Tullio, A.N., DeCarlo, E.,
Worrell, C.J., Steinberg, S.M., Flaherty, J., Yale, K., Kearney, B.P., and Zeichner,
S.L. (2005) Tenofovir disoproxil fumarate and an optimized background
regimen of antiretroviral agents as salvage therapy for pediatric HIV infection.
Pediatrics 116: e846-e854. [Abstract] [Full-text
PDF
article] Maldarelli,
F. (2005) HIV drug resistance. In Zeichner, S.L.,
and Read, J.S., eds., Textbook of Pediatric HIV Care, Cambridge University Press,
New York, pp. 334-354. Sklar,
P.A., Masur, H., Grubb, J.R., Voell, J., Witek, J., Ono, A., Freed, E.O., and
Maldarelli, F. (2005) Pravastin does not have a consistent
antiviral effect in chronically HIV-infected individuals on antiretroviral therapy.
AIDS 19: 1109-1111. [PubMed
citation] [Full-text PDF
article] Chen,
J., Dang, Q., Unutmaz, D., Pathak, V.K., Maldarelli, F., Powell, D., and
Hu, W.-S. (2005) Mechanisms of nonrandom human immunodeficiency virus
type 1 infection and double infection: Preference in virus entry is important
but is not the sole factor. J. Virol. 79: 4140-4149. [Abstract] [Full-text
PDF article] Nikolenko,
G.N., Palmer, S., Maldarelli, F., Mellors, J.W., Coffin, J.M., and Pathak,
V.K. (2005) Mechanism for nucleoside analog-mediated abrogation of
HIV-1 replication: Balance between RNase H activity and nucleotide excision.
Proc. Natl. Acad. Sci. USA 102: 2093-2098. [Abstract] [Full-text
PDF
article] Palmer,
S., Kearney, M., Maldarelli, F., Halvas, E.K., Bixby, C.J., Bazmi, H.,
Rock, D., Falloon, J., Davey, R.T., Jr., Dewar, R.L., Metcalf, J.A., Hammer, S.,
Mellors, J.W., and Coffin, J.M. (2005) Multiple, linked human immunodeficiency
virus type 1 drug resistance mutations in treatment-experienced patients are missed
by standard genotype analysis. J. Clin. Microbiol. 43: 406-413.
[Abstract] [Full-text
PDF article] Maldarelli,
F. (2005) Detection of human immunodeficiency virus infection.
In Mandell, G.L., Bennett, J.E., and Dolin, R., eds., Principles and
Practice of Infectious Diseases, 6th edition, Vol. 1. Achaz,
G., Palmer, S., Kearney, M., Maldarelli, F., Mellors, J.W., Coffin, J.M.,
and Wakeley, J. (2004) A robust measure of HIV-1 population turnover
within chronically infected individuals. Mol. Biol. Evol. 21: 1902-1912. [Abstract] [Full-text
PDF
article] Dybul,
M., Nies-Kraske, E., Dewar, R., Maldarelli, F., Hallahan, C.W., Daucher,
M., Piscitelli, S.C., Ehler, L., Weigand, A., Palmer, S., Metcalf, J.A., Davey,
R.T., Rock Kress, D.M., Powers, A., Beck, I., Frenkel, L., Baseler, M., Coffin,
J., and Fauci, A.S. (2004) A proof-of-concept study of short-cycle
intermittent antiretroviral therapy with a once-daily regimen of didanosine, lamivudine,
and efavirenz for the treatment of chronic HIV infection. J. Infect. Dis.
189: 1974-1982. [Abstract] [Full-text
PDF
article] Kottilil,
S., Jagannatha, S., Lu, A., Liu, S., McLaughlin, M., Metcalf, J.A., Dewar, R.,
Campbell, C., Koratich, C., Maldarelli, F., Masur, H., and Polis, M.A.
(2004) Changes in hepatitis C viral response after initiation of highly
active antiretroviral therapy and control of HIV viremia in chronically co-infected
individuals. HIV Clin. Trials 5: 25-32. [Abstract]
Dang,
Q., Chen, J., Unutmaz, D., Coffin, J.M., Pathak, V.K., Powell, D., KewalRamani,
V.N., Maldarelli, F., and Hu, W.-S. (2004) Nonrandom HIV-1
infection and double infection via direct and cell-mediated pathways. Proc.
Natl. Acad. Sci. USA 101: 632-637. [Abstract] [Full-text
PDF
article] [Supporting
text] Palmer,
S., Wiegand, A.P., Maldarelli, F., Bazmi, H., Mican, J.M., Polis, M., Dewar,
R.L., Planta, A., Liu, S., Metcalf, J.A., Mellors, J.W., and Coffin, J.M.
(2003) New real-time reverse transcriptase-initiated PCR assay with single-copy
sensitivity for human immunodeficiency virus type 1 RNA in plasma. J. Clin.
Microbiol. 41: 4531-4536. [Abstract] [Full-text
PDF article] Kottilil,
S., Chun, T.W., Moir, S., Liu, S., McLaughlin, M., Hallahan, C.W., Maldarelli,
F., Corey, L., and Fauci, A.S. (2003) Innate immunity in human
immunodeficiency virus infection: Effect of viremia on natural killer cell
function. J. Infect. Dis. 187: 1038-1045. [Abstract] [Full-text
PDF
article] Maldarelli,
F. (2003) HIV-1 fitness and replication capacity: What are
they and can they help in patient management? Curr. Infect. Dis. Rep. 5:
77-84. [Abstract]
Maldarelli,
F. (2003) HIV drug resistance. In Zeichner,
S., and Read, J., eds., Handbook of Pediatric HIV Care, Cambridge University Press.
Maldarelli,
F. (2003) HIV drug resistance testing. In Zeichner,
S., and Read, J., eds., Manual of Pediatric HIV Care, Cambridge University Press.
Palmer,
S., Kearney, M., Maldarelli, F., Kottilil, S., Lucey, D., Metcalf, J.,
Rock, D., VanHoutte, M., Michels, L., Hertogs, K., Mellors, J., and Coffin, J.
(2002) Genetics of HIV-1 populations in acute and chronic infection.
Antiviral Ther. 7: S57. Maldarelli,
F. (2001) Meeting report: First HIV DRP Symposium 'Understanding Antiviral
Drug Resistance', Chantilly, Virginia, USA, December 3-6, 2000. Int. Antiviral
News 9: 36-39. [Full-text PDF
article*] Favaro,
J.P., Maldarelli, F., Arrigo, S.J., and Schmidt, M.G. (1999) Effect of
Rev on the cytoplasmic localization of intron-containing human immunodeficiency
virus type 1 RNA. Virology 255: 237-249. [Abstract] [Full-text
PDF
article] Neuveut,
C., Low, K.G., Maldarelli, F., Schmitt, I., Majone, F., Grassmann, R.,
and Jeang, K.T. (1998) Human T-cell leukemia virus type 1 Tax and cell cycle progression:
Role of cyclin D-cdk and p110Rb. Mol. Cell. Biol. 18: 3620-3632. [Abstract] [Full-text
PDF article] Maldarelli,
F., Xiang, C., Chamoun, G., and Zeichner, S.L. (1998) The expression of the
essential nuclear splicing factor SC35 is altered by human immunodeficiency virus
infection. Virus Res. 53: 39-51. [Abstract]
Smith, S.M.,
Maldarelli, F., and Jeang, K.T. (1997) Efficient expression by an alphavirus
replicon of a functional ribozyme targeted to human immunodeficiency virus type
1. J. Virol. 71: 9713-9721. [Abstract] [Full-text
PDF article] Hori,
K., Hatfield, D., Maldarelli, F., Lee, B.J., and Clouse, K.A. (1997) Selenium
supplementation suppresses tumor necrosis factor alpha-induced human immunodeficiency
virus type 1 replication in vitro. AIDS Res. Hum. Retroviruses 13: 1325-1332.
[Abstract]
Shibata,
R., Maldarelli, F., Siemon, C., Matano, T., Parta, M., Miller, G., Fredrickson,
T., and Martin, M.A. (1997) Infection and pathogenicity of chimeric simian-human
immunodeficiency viruses in macaques: Determinants of high virus loads and CD4
cell killing. J. Infect. Dis. 176: 362-373. [Abstract]
Freed, E.O.,
Englund, G., Maldarelli, F., and Martin, M.A. (1997) Phosphorylation of
residue 131 of HIV-1 matrix is not required for macrophage infection. Cell 88:
171-173. [Abstract] [Full-text
PDF
article] Fujita,
K., Maldarelli, F., and Silver, J. (1996) Bimodal down-regulation of CD4
in cells expressing human immunodeficiency virus type 1 Vpu and Env. J. Gen. Virol.
77: 2393-2401. [Abstract]
Berthold,
E., and Maldarelli, F. (1996) cis-Acting elements in human immunodeficiency
virus type 1 RNAs direct viral transcripts to distinct intranuclear locations. J. Virol. 70: 4667-4682. [Abstract] [Full-text
PDF
article] Maldarelli,
F., Sato, H., Berthold, E., Orenstein, J., and Martin, M.A. (1995) Rapid induction
of apoptosis by cell-to-cell transmission of human immunodeficiency virus type
1. J. Virol. 69: 6457-6465. [Abstract] [Full-text
PDF
article] *
Reprinted with permission from International
Medical Press.
Last
modified: 13 January 2009 | ... |