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Retroviruses
Book Online
The full
text of the book
Retroviruses (edited by John M. Coffin, Stephen H. Hughes, and
Harold E. Varmus, 1997, Cold Spring Harbor Laboratory Press) is now available
online at the National Center for Biotechnology Information website. Figures,
tables, and retrotrivia features from the book are also available at this website.
(Permission to depict the book's cover here was kindly granted by the publisher.)
Virology Core
Under
the direction of Dr.
Mary Kearney, the DRP-dedicated Virology Core is conducting analyses
of HIV samples from clinical and basic studies on HIV, which will provide new
and important information on viral dynamics, genetics, and evolution both in
vitro and in vivo. Dr. Kearney is working closely with Dr.
Frank Maldarelli in the Clinical Program, in consultation with Dr.
John Coffin of Tufts University and Dr.
John Mellors of the University of Pittsburgh, to develop methods
for obtaining very large numbers of sequences from virus circulating in plasma
and for measuring virus load with much greater sensitivity than can be reliably
attained with currently available tests. As part of this work, the Virology Core
is using a range of techniques such as limiting-dilution polymerase chain reaction
(PCR), allele-specific PCR, site-directed mutagenesis, and viral load monitoring.
NCI-Frederick
Resources
In addition to the DRP-dedicated Virology Core, the research support capabilities
that are available on the NCI-Frederick campus provide the DRP with a large variety
of resources, including
Last
modified: 31 July 2008 | ... |