Summaries & Associations of Study Results
TR-358 Ochratoxin A
Target Organs and Levels of Evidence
NTP Technical Report Number 358
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| OCHRATOXIN A 303-47-9 |
04/18/88 | NATURALLY OCCURRING FUNGAL TOXIN; CONTAMINANT IN CORN, PEANUTS, STORAGE GRAINS, COTTONSEED, MEATS, DRIED FISH,AND NUTS. | Gavage R: 0, 21, 70, 210 MG/KG | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: RENAL TUBULE, EPITHELIUM, HYPERPLASIA 1/50 1/51 16/51 24/50, PROLIFERATION 0/50 0/51 10/51 26/50, CYTOPLASMIC ALTERATION 1/50 0/51 3/51 8/50, KARYOMEGALY 0/50 1/51 51/51 50/50, DEGENERATION 0/50 0/51 50/51 49/50 | |||
| FR: CLEAR EVIDENCE | KIDNEY TUBULAR CELL: ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50 | |||
| MAMMARY GLAND: FIBROADENOMA 17/50 23/51 22/50 28/50 | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: RENAL TUBULE, EPITHELIUM, HYPERPLASIA 0/50 0/51 12/50 13/50, PROLIFERATION 0/50 0/51 3/50 16/50, KARYOMEGALY 0/50 8/51 50/50 50/50, DEGENERATION 0/50 0/51 49/50 49/50 | |||
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