Unusual sulfamate indoles and a novel indolo[3,2-a]carbazole from Ancorina sp.

Meragelman, K.M., West, L.M., Northcote, P.T., Pannell, L.K., McKee, T.C., and Boyd, M.R.: J.Org.Chem. 67: 6671-6677, 2002.

Abstract:

Four new indoles, ancorinolates A-C and bis-ancorinolate B, which contain sulfamate and sulfate groups, were isolated from the aqueous extract of the sponge Ancorina sp. In addition, ancorinazole, an indolo[3,2-a]carbazole also possessing sulfamate and sulfate groups, was isolated from two separate New Zealand collections of Ancorina sp. Ancorinazole is the first indolo[3,2-a]carbazole described as a natural product. Ancorinolates A (1) and C (3) showed weak HIV-inhibitory activity in the XTT-based, anticytopathicity assay.

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