Contact Information

Jacco de Zwart
10 Center Dr.
Bldg. 10, Rm. B1D-726 - MSC 1065
Bethesda, MD 20892-1065
USA
Tel.: +1 301 594 7315
Fax: +1 301 480 1981
E-mail: Jacco.deZwart at nih . gov

Previous Positions

• 2000-2003, Visiting Fellow, National Institutes of Health, NINDS, Advanced MRI Section, LFMI
• 1995-1996, Guest Researcher, National Institutes of Health, NCRR, In Vivo NMR Research Center

Education

• Ph.D.:
  • Université Victor Segalen Bordeaux II, Bordeaux, France, Biologie Santé (Medical Biology), February 2000
  • Universiteit Utrecht, Utrecht, the Netherlands, Geneeskunde (Medicine), May 2000
    • Based on a joint thesis agreement with Université Victor Segalen
  • Thesis entitled: "Fast magnetic resonance temperature imaging for control of localized hyperthermia in medicine." ISBN 90-393-2362-3
• M.Sc.: Moleculaire Wetenschappen (Molecular Sciences), Landbouwuniversiteit Wageningen (WAU), Wageningen, the Netherlands, July 1995
  • Masters' Theses:
  • "Fast MRI thermometry ", In Vivo NMR Research Center (NCRR, NIH, Bethesda, MD, USA), July 1995
  • "Time resolved imaging microscopy in Wageningen", Department of Biochemistry (WAU), December 1994
  • "Diffusie en perfusiemetingen - PFG NMR & NMR imaging" (in Dutch), Department of Molecular Physics (WAU), January 1994

Publications

• JA de Zwart, P Gelderen, M Fukunaga, JH Duyn
  Reducing correlated noise in fMRI data.
  Magn Reson Med 2008 59:939-45
• P van Gelderen, JA de Zwart, JH Duyn
  Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling.
  Magn Reson Med 2008 59:788-95
• M Fukunaga, SG Horovitz, JA de Zwart, P van Gelderen, TJ Balkin, AR Braun, JH Duyn
  Metabolic origin of BOLD signal fluctuations in the absence of stimuli.
  J Cereb Blood Flow Metab 2008 28:1377-87
• SG Horovitz, M Fukunaga, JA de Zwart, P van Gelderen, SC Fulton, TJ Balkin, JH Duyn
  Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study.
  Hum Brain Mapp 2008 29:671-82


• K Shmueli, P van Gelderen, JA de Zwart, SG Horovitz, M Fukunaga, JM Jansma, JH Duyn
  Low-frequency fluctuations in the cardiac rate as a source of variance in the resting-state fMRI BOLD signal.
  Neuroimage 2007 38:306-20
• JH Duyn, P van Gelderen, TQ Li, JA de Zwart, AP Koretsky, M Fukunaga
  High-field MRI of brain cortical substructure based on signal
  Proc Natl Acad Sci U S A 2007 104:11796-801
• P van Gelderen, JA de Zwart, P Starewicz, RS Hinks, JH Duyn
  Real-time shimming to compensate for respiration-induced B0 fluctuations.
  Magn Reson Med 2007 57:362-8
• JM Jansma, NF Ramsey, JA de Zwart, P van Gelderen, JH Duyn
  fMRI study of effort and information processing in a working memory task.
  Hum Brain Mapp 2007 28:431-40


• JM Jansma, NF Ramsey, JA de Zwart, P van Gelderen, JH Duyn
  fMRI study of effort and information processing in a working memory task.
  Hum Brain Mapp 2006
• RH Deckers, P van Gelderen, M Ries, O Barret, JH Duyn, VN Ikonomidou, M Fukunaga, GH Glover, JA de Zwart
  An adaptive filter for suppression of cardiac and respiratory noise in MRI time series data.
  Neuroimage 2006 33:1072-81
• M Fukunaga, SG Horovitz, P van Gelderen, JA de Zwart, JM Jansma, VN Ikonomidou, R Chu, RH Deckers, DA Leopold, JH Duyn
  Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages.
  Magn Reson Imaging 2006 24:979-92
• JA de Zwart, P van Gelderen, X Golay, VN Ikonomidou, JH Duyn
  Accelerated parallel imaging for functional imaging of the human brain.
  NMR Biomed 2006 19:342-51


• JH Duyn, P van Gelderen, L Talagala, A Koretsky, JA de Zwart
  Technological advances in MRI measurement of brain perfusion.
  J Magn Reson Imaging 2005 22:751-753
• P van Gelderen, CW Wu, JA de Zwart, L Cohen, M Hallett, JH Duyn
  Resolution and reproducibility of BOLD and perfusion functional MRI at 3.0 Tesla.
  Magn Reson Med 2005 54:569-576
• VN Ikonomidou, P van Gelderen, JA de Zwart, M Fukunaga, JH Duyn
  Optimizing brain tissue contrast with EPI: a simulated annealing approach.
  Magn Reson Med 2005 54:373-85
• JA de Zwart, AC Silva, P van Gelderen, P Kellman, M Fukunaga, R Chu, AP Koretsky, JA Frank, JH Duyn
  Temporal dynamics of the BOLD fMRI impulse response.
  Neuroimage 2005 24:667-677


• R Chu, JA de Zwart, P van Gelderen, M Fukunaga, P Kellman, T Holroyd, JH Duyn
  Hunting for neuronal currents: absence of rapid MRI signal changes during visual-evoked response.
  Neuroimage 2004 23:1059-67
• X Golay, JA de Zwart, YC Ho, YY Sitoh
  Parallel imaging techniques in functional MRI.
  Top Magn Reson Imaging 2004 15:255-65
• J Bodurka, PJ Ledden, P van Gelderen, R Chu, JA de Zwart, D Morris, JH Duyn
  Scalable multichannel MRI data acquisition system.
  Magn Reson Med 2004 51:165-71
• JA de Zwart, PJ Ledden, P van Gelderen, J Bodurka, R Chu, JH Duyn
  Signal-to-noise ratio and parallel imaging performance of a 16-channel receive-only brain coil array at 3.0 Tesla.
  Magn Reson Med 2004 51:22-6


• P Kellman, P Gelderen, JA de Zwart, JH Duyn
  Method for functional MRI mapping of nonlinear response.
  Neuroimage 2003 19:190-9
• E Guilhon, P Voisin, JA de Zwart, B Quesson, R Salomir, C Maurange, V Bouchaud, P Smirnov, H de Verneuil, A Vekris, P Canioni, CT Moonen
  Spatial and temporal control of transgene expression in vivo using a heat-sensitive promoter and MRI-guided focused ultrasound.
  J Gene Med 2003 5:333-42


• JA de Zwart, P van Gelderen, P Kellman, JH Duyn
  Application of sensitivity-encoded echo-planar imaging for blood oxygen level-dependent functional brain imaging.
  Magn Reson Med 2002 48:1011-20
• JA de Zwart, P van Gelderen, P Kellman, JH Duyn
  Reduction of gradient acoustic noise in MRI using SENSE-EPI.
  Neuroimage 2002 16:1151-5
• JA de Zwart, PJ Ledden, P Kellman, P van Gelderen, JH Duyn
  Design of a SENSE-optimized high-sensitivity MRI receive coil for brain imaging.
  Magn Reson Med 2002 47:1218-27
• B Quesson, F Vimeux, R Salomir, JA de Zwart, CT Moonen
  Automatic control of hyperthermic therapy based on real-time Fourier analysis of MR temperature maps.
  Magn Reson Med 2002 47:1065-72


• CT Moonen, B Quesson, R Salomir, FC Vimeux, JA de Zwart, JJ van Vaals, N Grenier, J Palussiere
  Thermal therapies in interventional MR imaging. Focused ultrasound.
  Neuroimaging Clin N Am 2001 11:737-47, xi
• JA de Zwart, FC Vimeux, J Palussiere, R Salomir, B Quesson, C Delalande, CT Moonen
  On-line correction and visualization of motion during MRI-controlled hyperthermia.
  Magn Reson Med 2001 45:128-37


• R Salomir, J Palussiere, FC Vimeux, JA de Zwart, B Quesson, M Gauchet, P Lelong, J Pergrale, N Grenier, CT Moonen
  Local hyperthermia with MR-guided focused ultrasound: spiral trajectory of the focal point optimized for temperature uniformity in the target region.
  J Magn Reson Imaging 2000 12:571-83
• B Quesson, JA de Zwart, CT Moonen
  Magnetic resonance temperature imaging for guidance of thermotherapy.
  J Magn Reson Imaging 2000 12:525-33
• R Salomir, FC Vimeux, JA de Zwart, N Grenier, CT Moonen
  Hyperthermia by MR-guided focused ultrasound: accurate temperature control based on fast MRI and a physical model of local energy deposition and heat conduction.
  Magn Reson Med 2000 43:342-7
  


• JA de Zwart, FC Vimeux, C Delalande, P Canioni, CT Moonen
  Fast lipid-suppressed MR temperature mapping with echo-shifted gradient-echo imaging and spectral-spatial excitation.
  Magn Reson Med 1999 42:53-9
• C Delalande, JA de Zwart, H Trillaud, N Grenier, CT Moonen
  An echo-shifted gradient-echo MRI method for efficient diffusion weighting.
  Magn Reson Med 1999 41:1000-8
• FC Vimeux, JA De Zwart, J Palussiere, R Fawaz, C Delalande, P Canioni, N Grenier, CT Moonen
  Real-time control of focused ultrasound heating based on rapid MR thermometry.
  Invest Radiol 1999 34:190-3


• DP Madio, P van Gelderen, D DesPres, AW Olson, JA de Zwart, TW Fawcett, NJ Holbrook, M Mandel, CT Moonen
  On the feasibility of MRI-guided focused ultrasound for local induction of gene expression.
  J Magn Reson Imaging 1998 8:101-4


• JA de Zwart, P van Gelderen, DJ Kelly, CT Moonen
  Fast magnetic-resonance temperature imaging.
  J Magn Reson B 1996 112:86-90

Book Chapters

• CTW Moonen, JA de Zwart, FC Vimeux, J Palussière, N Grenier, P Voisin, A Vekris, P Canioni, P van Gelderen, J Pergrale, P Lelong, E Dumont, J van Vaals
  Towards real-time control of local hyperthermia based on fast MR temperature mapping.
  In: "Excerpta Medica International Congress Series 1192-R" (ISBN 0-444-50280-7) S. Naruse, H. Watari (eds.) 1999 277-284

Patents

• CTW Moonen, R Salomir, F Vimeux, J de Zwart
  Ensemble de traitement thermique de tissus biologiques et procédé de mise en oevre de cet ensemble.
  Patent Number: 00962605.2-2305, France 2000

Grants Received

• National Institutes of Health, NINDS competitive fellowship award
  Improved Functional MRI Using Multiple Surface Coils.
  Jan 1, 2002 - Aug 21, 2003
• European Commission, Marie Curie TMR research grant ERBFMBICT961733
  Ultra Fast Non Invasive Imaging of Temperature for Application In Gene Therapy and Tumor Ablation.
  Apr 1, 1997 - Mar 31, 2000