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Person Details

Superfund Basic Research Program

Andrew J. Wyrobek

Lawrence Livermore National Laboratory
Health Effects Genetics Division, L-448
Biology and Biotechnology Research Program
Berkeley, CA 94551
Phone: 925-422-6296
Fax: 925-424-3130
Email:

Projects

Research Briefs

Publications

2008
  • Young, Suzanne S., Brenda Eskenazi, Francesco Marchetti, Gladys Block, and Andrew J. Wyrobek. 2008. The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Human Reproduction. (http://humrep.oupjournals.org/) Exit NIEHS Website doi:10.1093/humrep/den036 (http://dx.doi.org/10.1093/humrep/den036) Exit NIEHS Website23(5):1014-22.
2005
  • Eskenazi, Brenda, Sharon A. Kidd, Amy R. Marks, Eddie Sloter, Gladys Block, and Andrew J. Wyrobek. 2005. Antioxidant intake is associated with semen quality in healthy men. Human Reproduction. (http://humrep.oupjournals.org/) Exit NIEHS Website 20(4):1006-1012.
  • Wyrobek, Andrew J., Thomas E. Schmid, and Francesco Marchetti. 2005. Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 45(2-3):271-283.
  • Wyrobek, Andrew J., Thomas E. Schmid, and Francesco Marchetti. 2005. Relative susceptibilities of male germ cells to genetic defects induced by cancer chemotherapies. Journal of the National Cancer Institute. (http://jncicancerspectrum.oupjournals.org/) Exit NIEHS Website 34:31-35.
2004
  • Sloter, Eddie, Joginder Nath, Brenda Eskenazi, and Andrew J. Wyrobek. 2004. Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents. Fertility and Sterility. (http://www.sciencedirect.com/science/journal/ 00150282) Exit NIEHS Website 81(4):925-943.
2003
  • Eskenazi, Brenda, Andrew J. Wyrobek, Eddie Sloter, Sharon A. Kidd, Suzanne S. Young, and Dan H. Moore. 2003. The association of age and semen quality in healthy men. Human Reproduction. (http://humrep.oupjournals.org/) Exit NIEHS Website 18(2):447-454.
  • Glaser, Rivka L., Karl W. Broman, Rebecca L. Schulman, Brenda Eskenazi, Andrew J. Wyrobek, and Ethylin Wang Jabs. 2003. The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. American Journal of Human Genetics. (http://www.journals.uchicago.edu/AJHG/journal /) Exit NIEHS Website 73(4):939-947.
2002
  • Eskenazi, Brenda, Andrew J. Wyrobek, Sharon A. Kidd, Xiu Lowe, Dan H. Moore, K. Weisiger, and Melissa Aylstock. 2002. Sperm aneuploidy in fathers of children with paternally and maternally inherited Klinefelter syndrome. Human Reproduction. (http://humrep.oupjournals.org/) Exit NIEHS Website 17(3):576-583.
  • Eskenazi, Brenda, Andrew J. Wyrobek, Eddie Sloter, Sharon A. Kidd, Lee E. Moore, Suzanne S. Young, and Dan H. Moore. 2002. Semen quality and chromosomal integrity of sperm decreases with age among healthy men. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 39(Supp33):59.
  • Rubes, Jiri, Miluse Vozdova, Wendie A. Robbins, Olga Rezacova, Sally D. Perreault, and Andrew J. Wyrobek. 2002. Stable Variants of Sperm Aneuploidy among Healthy Men Show Associations between Germinal and Somatic Aneuploidy. American Journal of Human Genetics. (http://www.journals.uchicago.edu/AJHG/journal /) Exit NIEHS Website 70(6):1507-1519.
  • Sloter, Eddie, Brenda Eskenazi, Joginder Nath, Dan H. Moore, Sharon A. Kidd, and Andrew J. Wyrobek. 2002. Semen quality and chromosomal integrity of sperm decreases with age among healthy men. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 39(Suppl.33):59.
  • Tiemann-Boege, Irene, William Navidi, Raji Grewal, Dan Cohn, Brenda Eskenazi, Andrew J. Wyrobek, and Norman Arnheim. 2002. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 99(23):14952-14957.
  • Velazquez-Wong, Ana Claudia, Eddie Sloter, Lisa M. Tomascik-Cheeseman, M. Antonieta Araujo-Solis, Andrew J. Wyrobek, and Fabio Salamanca-Gomez. 2002. Structural and numerical chromosomal abnormalities in sperm following accidental occupational exposure to 192Iridium. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 39(Supp33):65.
2001
  • Kidd, Sharon A., Brenda Eskenazi, and Andrew J. Wyrobek. 2001. Effects of male age on semen quality and fertility: a review of the literature. Fertility and Sterility. (http://www.sciencedirect.com/science/journal/ 00150282) Exit NIEHS Website 75(2):237-248.
  • Lowe, Xiu, Brenda Eskenazi, David O. Nelson, Sharon A. Kidd, Angela Alme, and Andrew J. Wyrobek. 2001. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. American Journal of Human Genetics. (http://www.journals.uchicago.edu/AJHG/journal /) Exit NIEHS Website 69(5):1046-1054.
  • Marchetti, Francesco, Eddie Sloter, and Andrew J. Wyrobek. 2001. Advances in understanding paternally transmitted chromosomal abnormalities. In: Impact of air pollution on human health. Academia Press, Prague, Czech Republic. pp.193-205.
  • Sloter, Eddie, Brenda Eskenazi, Sharon A. Kidd, Dan H. Moore, F. Hill, Joginder Nath, and Andrew J. Wyrobek. 2001. Effects of age on structural chromosomal abnormalities in sperm from healthy men. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 37(32):70.
2000
  • Sloter, Eddie, Joginder Nath, and Andrew J. Wyrobek. 2000. Associations between chromosomal abnormalities and semen quality in healthy men. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 35(31):57.
1999
  • Holland, Nina T., Thomas Ahlborn, Kenneth W. Turteltaub, C. Markee, Dan H. Moore, Andrew J. Wyrobek, and Martyn T. Smith. 1999. Acrylamide causes preimplantation abnormalities in embryos and induces chromatin-adducts in male germ cells of mice. Reproductive Toxicology. (http://www.sciencedirect.com/science/journal/ 08906238) Exit NIEHS Website 13(3):167-178.
  • Sloter, Eddie, Joginder Nath, and Andrew J. Wyrobek. 1999. Correlation between numerical and structural chromosome damage in sperm from 13 healthy men using multicolor FISH. American Journal of Human Genetics. (http://www.journals.uchicago.edu/AJHG/journal /) Exit NIEHS Website 65(4):A357.
1998
  • Eskenazi, Brenda, Y-J Chuu, Sharon A. Kidd, Xiu Lowe, Melissa Aylstock, K. Weisiger, Dan H. Moore, and Andrew J. Wyrobek. 1998. Elevated frequencies of aneuploid sperm (x-y and 21-21) in fathers of boys with klinefelter syndrome (47, x-x-y), when the extra x-chromosome was of paternal origin. American Journal of Epidemiology. (http://www.aje.oupjournals.org/) Exit NIEHS Website 147(11):S11.
  • Lowe, Xiu, Brenda Eskenazi, Sharon A. Kidd, Angela Alme, K. Weisiger, Melissa Aylstock, D.E. Nelson, and Andrew J. Wyrobek. 1998. Sperm disomy 21 is associated with sex chromosomal aneuploidies but does not preferentially segregate with the Y chromosome: a study of 38 healthy fertile men. American Journal of Human Genetics. (http://www.journals.uchicago.edu/AJHG/journal /) Exit NIEHS Website 63(4):A143.
  • Sloter, Eddie, Xiu Lowe, Joginder Nath, and Andrew J. Wyrobek. 1998. A novel multi-color FISH method for human sperm demonstrates that post-meiotic chromosome breaks occur more frequently than duplications and deletions. American Journal of Human Genetics. (http://www.journals.uchicago.edu/AJHG/journal /) Exit NIEHS Website 63(4):A150.
  • Sloter, Eddie, Xiu Lowe, Joginder Nath, and Andrew J. Wyrobek. 1998. Detection of chromosome breaks and aneuploidies in human sperm by multicolor fluorescence in situ hybridization. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 31(29):61.
  • Titenko-Holland, Nina, Thomas Ahlborn, Xiu Lowe, Nong Shang, Martyn T. Smith, and Andrew J. Wyrobek. 1998. Micronucleal and developmental abnormalities in 4-day mouse embryos after paternal treatment with acrylamide. Environmental and Molecular Mutagenesis. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=10009058) Exit NIEHS Website 31(3):206-217.
  • Wyrobek, Andrew J., Brenda Eskenazi, Y-J Chuu, Sharon A. Kidd, Xiu Lowe, K. Weisiger, Melissa Aylstock, Eddie Sloter, Dan H. Moore, and D. Katz. 1998. Genetic Biomarkers in Human Sperm: Applications in Reproductive Epidemiology. In: Proceedings Superfund Basic Research Program: A Decade of Improving Health through Multi-Disciplinary Research. Chapel Hill, NC.
1997
  • Chuu, Y-J, Xiu Lowe, Sharon A. Kidd, K. Weisiger, Brenda Eskenazi, and Andrew J. Wyrobek. 1997. Elevated Frequencies Of Hyperhaploid Sperm Were Detected In A Man With A History Of Multiple Aneuploid Pregnancies. In: Proceedings of Environmental Mutagen Society Meeting, 1997. Minneapolis, MN.
  • Robbins, Wendie A., Marvin L. Meistrich, Dan H. Moore, Fredrick B. Hagemeister, Heinz-Ulrich Weier, Michael J. Cassel, Gene Wilson, Brenda Eskenazi, and Andrew J. Wyrobek. 1997. Chemotherapy induces transient sex chromosomal and autosomal aneuploidy in human sperm. Nature Genetics. (http://www.nature.com/ng/) Exit NIEHS Website 16:74-78.
  • Wyrobek, Andrew J., Brenda Eskenazi, Y-J Chuu, Sharon A. Kidd, Xiu Lowe, K. Weisiger, Melissa Aylstock, Eddie Sloter, Dan H. Moore, and D. Katz. 1997. Genetic biomarkers in human sperm: Applications in reproductive epidemiology. In: Proceedings of the Superfund Basic Research Program: A decade of improving health through multi-disciplinary research, Chapel Hill, NC, February 23-26, 1997. Chapel Hill, NC.
1995
  • Titenko-Holland, Nina, Kenneth W. Turteltaub, Andrew J. Wyrobek, and Martyn T. Smith. 1995. Acrylamide induces DNA adducts in male germ cells and causes preimplantation abnormalities and dominant lethal mutations in mice. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 15(1):167.
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Last Reviewed: 19 May 2008