National Toxicology Program

CASRN: 2832-40-8

Formula: C15-H15-N3-O2

Synonyms/Common Names:

• N-(4-((2-HYDROXY-5-METHYLPHENYL)AZO)PHENYL)ACETAMIDE (9CI)
• YELLOW 3, C.I. DISPERSE

Known Uses:

MONOAZO DYE IN NYLON, WOOL, FUR, POLYVINYL CHLORIDE, ACRYLIC FIBERS, POLYSTYRENE, OTHER THERMOPLASTICS

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C53781) Completed 
  • NTIS No. PB82-230061  (Peer Review 02/18/1981)
    Citation: Carcinogenesis Bioassay of Disperse Yellow 3 (CAS No. 2832-40-8) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C53781) Completed 
  • NTIS No. PB82-230061  (Peer Review 02/18/1981)
    Citation: Carcinogenesis Bioassay of Disperse Yellow 3 (CAS No. 2832-40-8) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1250,20000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C53781) Report Complete 
  • TR-222 (NTIS No. PB82-230061)  (Peer Review 02/18/1981)
    Carcinogenesis Bioassay of Disperse Yellow 3 (CAS No. 2832-40-8) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Positive 
  • Dose: R: 0,5000,10000, M: 0,2500,5000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (221078) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (041446) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (394201) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (571100) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Micronucleus  (960034) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (328289) Completed 
  •  Positive 
• Salmonella  (376537) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Sister Chromatid Exchanges  (221078) Completed 
  • Mice
  • Sister Chromatid  Positive