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Copyright © Ohkura-Hada et al.; Licensee Bentham Open. Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy 1Department of Biochemistry, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi 2Department of Oral surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi 3Department of Oral Diagnosis, Hokkaido University Graduate School of Dental Medicine, Sapporo-shi 4Department of Oral Pathology and Diagnosis, Hokkaido University Graduate School of Dental Medicine, Sapporo-shi 5Department of Biochemistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho-shi, Japan *Address correspondence to this author at the Department of Biochemistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho-shi, Gifu-ken, 501-0296, Japan E-mail: nkondoh/at/dent.asahi-u.ac.jp Received February 19, 2008; Revised March 19, 2008; Accepted May 9, 2008. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. | ||||
Abstract The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy. | ||||
