Office of the Director, HIV Drug Resistance Program

Stephen H. Hughes, Ph.D., Director

Stephen Oroszlan, Ph.D., Scientist Emeritus

Retroviral Replication Laboratory

Stephen H. Hughes, Ph.D., Chief, Retroviral Replication Laboratory; Head, Vector Design and Replication Section

• Retroviral replication
• Structure and function of HIV reverse transcriptase
• Retroviral vectors

David Derse, Ph.D., Head, Retrovirus Gene Expression Section

• Comparative retrovirology
• Mechanisms of HIV-1 and HTLV-1 infection and replication
• Control of cell and virus gene expression
• Viral pathogenesis and persistence

Eric O. Freed, Ph.D., Head, Virus-Cell Interaction Section

• HIV and retroviral assembly and release
• Interactions between viral and cellular proteins
• Trafficking of retroviral proteins
• Envelope glycoprotein incorporation and function

Wei-Shau Hu, Ph.D., Head, Viral Recombination Section

• Mechanisms of reverse transcription and recombination
• RNA packaging and virus assembly
• HIV replication
• Interactions between distinct viruses

Vineet N. KewalRamani, Ph.D., Head, Model Development Section

• Virus-host interactions
• Cofactors in HIV infection
• Development of animal models for HIV infection

Stuart F.J. Le Grice, Ph.D., Head, RT Biochemistry Section

• Protein and nucleic acid footprinting
• Bioconjugate evaluation of reverse transcription complexes
• RNase H inhibitors
• Unnatural amino acids as probes of protein function

Vinay K. Pathak, Ph.D., Head, Viral Mutation Section

• Structure and function of APOBEC3 host restriction factors
• Mechanisms of antiviral drug resistance
• Reverse transcriptase structure, fidelity, and template switching

Alan Rein, Ph.D., Head, Retrovirus Assembly Section

• Molecular mechanisms of retroviral assembly and replication
• Interactions of retroviral proteins with nucleic acids
• Interactions of retroviral components with host antiviral factors

Host-Virus Interaction Branch

Frank Maldarelli, M.D., Ph.D., Head, In Vivo Biology Group

• HIV-1 population genetics in vivo
• Source of low-level viremia in patients suppressed on antiretroviral therapy
• Clinical studies on HIV resistance

Mary Kearney, Ph.D., Manager, Virology Core Facility

CONSULTANTS:

John M. Coffin, Ph.D., American Cancer Society Research Professor, Tufts University

John W. Mellors, M.D., Chief, Division of Infectious Diseases, University of Pittsburgh

Last modified: 4 August 2008