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UGID:230017     UniGene Hs.434980     Homo sapiens (human)   APP Order cDNA clone, Links
Amyloid beta (A4) precursor protein (APP)
SELECTED PROTEIN SIMILARITIES
Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.
Reference ProteinSpeciesId(%)Len(aa)
NP_000475.1 amyloid beta A4 protein precursor, isoform a H. sapiens 100.0 769

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
Expression Profile: View expression levels using UniGene's EST ProfileViewer
[Show more entries with profiles like this]
Note: Highly represented in many libraries
GEO profiles: Gene expression profiles in the NCBI Gene Expression Omnibus database
cDNA Sources: brain; testis; intestine; embryonic tissue; uncharacterized tissue; eye; mammary gland; thyroid; kidney; pancreas; lung; placenta; uterus; mouth; skin; connective tissue; trachea; mixed; stomach; prostate; vascular; adrenal gland; nerve; bladder; ganglia; amniotic fluid; ovary; blood; parathyroid; ascites; heart; umbilical cord; bone; thymus; pituitary gland; liver; cervix; pharynx; ear; muscle; larynx; epididymis; spinal cord; salivary gland; spleen; esophagus; lymph node; bone marrow; adipose tissue
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 21
Map position: 21q21.2|21q21.3
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (32)

AF282245.1 Homo sapiens amyloid precursor protein 639 (APP639) mRNA, complete cds P
NM_000484.2 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1, mRNA PA
M16765.1 Human cerebrovascular and neuritic plaque amyloid beta-protein mRNA, 3' end P
NM_201414.1 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 3, mRNA PA
NM_201413.1 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 2, mRNA PA
BC065529.1 Homo sapiens amyloid beta (A4) precursor protein, mRNA (cDNA clone MGC:75167 IMAGE:6152423), complete cds PA
BC065523.1 Homo sapiens amyloid beta (A4) precursor protein, mRNA (cDNA clone IMAGE:6007573), complete cds PA
CR618842.1 full-length cDNA clone CS0DN005YC23 of Adult brain of Homo sapiens (human) P
CR618347.1 full-length cDNA clone CS0DN001YE01 of Adult brain of Homo sapiens (human) P
M28373.1 Homo sapiens amyloid protein A4 precursor mRNA, 3' end of cds P
BC004369.1 Homo sapiens amyloid beta (A4) precursor protein, mRNA (cDNA clone IMAGE:3639599), complete cds PA
BC110059.1 Homo sapiens cDNA clone IMAGE:40009144
AK311717.1 Homo sapiens cDNA, FLJ18759
AK312326.1 Homo sapiens cDNA, FLJ92638, Homo sapiens amyloid beta (A4) precursor protein (proteasenexin-II, Alzheimer disease) (APP), mRNA
Y00264.1 Human mRNA for amyloid A4 precursor of Alzheimer's disease P
X06989.1 Homo sapiens mRNA for amyloid A4 protein (APP gene) P
AK294534.1 Homo sapiens cDNA FLJ50491 complete cds, highly similar to Amyloid beta A4 protein precursor (APP) (ABPP)(Alzheimer disease amyloid protein) (Cerebral vascularamyloid peptide) (CVAP) (Protease nexin-II) (PN-II)(APPI) (PreA4) [Contains: Soluble APP-al ...
AK297412.1 Homo sapiens cDNA FLJ54261 complete cds, highly similar to Homo sapiens amyloid beta (A4) precursor protein, transcript variant 3, mRNA
AK297229.1 Homo sapiens cDNA FLJ54367 complete cds, highly similar to Amyloid beta A4 protein precursor (APP) (ABPP)(Alzheimer disease amyloid protein homolog) [Contains:Soluble APP-alpha (S-APP-alpha); Soluble APP-beta(S-APP-beta); C99; Beta-amyloid protein 42 ...
AK298861.1 Homo sapiens cDNA FLJ51942 complete cds, highly similar to Homo sapiens amyloid beta (A4) precursor protein, transcript variant 3, mRNA
AK296229.1 Homo sapiens cDNA FLJ59550 complete cds, highly similar to Homo sapiens amyloid beta (A4) precursor protein, transcript variant 3, mRNA
AK295621.1 Homo sapiens cDNA FLJ50531 complete cds, highly similar to Amyloid beta A4 protein precursor (APP) (ABPP)(Alzheimer disease amyloid protein homolog) [Contains:Soluble APP-alpha (S-APP-alpha); Soluble APP-beta(S-APP-beta); C99; Beta-amyloid protein 42 ...
AB066441.2 Homo sapiens APP mRNA for amyloid precursor protein, partial cds, D678N mutant P
S61383.1 beta-amyloid peptide precursor {clone 3} [human, mRNA Partial Mutant, 246 nt] P
S61380.1 beta-amyloid peptide precursor {clone 2} [human, mRNA Partial Mutant, 246 nt] P
S60721.1 beta-amyloid peptide precursor {clone 1} [human, mRNA Partial Mutant, 246 nt] P
S41243.1 amyloid protein precursor {3' region, alternative polyadenylation, long mRNA} [human, brain, mRNA Partial, 337 nt]
X06982.1 Homo sapiens partial mRNA for amyloid beta-protein (APP gene) P
X06981.1 Human mRNA fragment for amyloid beta-protein (AP) insertion P
M35675.1 Human amyloid beta precursor protein (ABPP) mRNA, 5' end
M18734.1 Human beta-amyloid A4 mRNA, partial cds P
M15533.1 Human amyloid protein (AD-AP) mRNA, 3' end P

EST sequences (10 of 2533) [Show all sequences]

AA865515.1 Clone IMAGE:1459289 kidney 3' read A
AA984378.1 Clone IMAGE:1629881 brain 3' read P
R19709.1 Clone IMAGE:34389 brain 5' read P
AI079842.1 Clone IMAGE:1659749 embryonic tissue 3' read A
AI081493.1 Clone IMAGE:1679096 skin 3' read A
AI089756.1 Clone IMAGE:1687512 brain 3' read A
CA975986.1 Clone IMAGE:6202385 nerve 5' read P
AI094750.1 Clone IMAGE:1686215 brain 3' read A
AI123982.1 Clone IMAGE:1694894 uterus 3' read A
AI124771.1 Clone IMAGE:1540103 brain 3' read P


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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