Drug Discovery for Diabetes, Endocrine, and Metabolic Diseases : NIDDK

Drug Discovery for Diabetes, Endocrine, and Metabolic Diseases

The drug discovery program for diabetes, endocrine and metabolic diseases supports/promotes:

a) Interdisciplinary activities and resources that increase understanding of physiological and pathophysiological processes relevant to therapeutic development in diabetes, endocrine and metabolic disorders.

b) Research that seeks the elucidation of molecular structures or biological pathways that may lead to the identification and validation of targets that can be potentially manipulated by ligands/inhibitors. “Druggable” molecular targets/pathways.

c) Research of the potential bioavailability of compounds, the ability to modulate selectively the function of drug discovery targets, and the ability to translate biological endpoints of preclinical research to the clinic showing high potential for success in later stage drug development.

d) Development of high throughput assays based on biologic pathways likely involved in the pathogenesis of diabetes and its complications that could be used to screen molecular libraries for novel therapeutic agents.

e) Research that seeks the discovery of new mechanisms of action for therapeutics used for diabetes, endocrine and metabolic disorders; and the development and validation of disease models to evaluate novel therapeutics for these disorders.

For more information, contact Dr. Guillermo Arreaza-Rubin, Director, Clinical Immunology, Type 1 Diabetes Program.

Resources for Researchers

Clinical Research


Funding for Special Communities


Funding Opportunities


Related Study Sections

See Also

Page last updated: January 20, 2009

General inquiries may be addressed to: Office of Communications & Public Liaison
Building 31. Rm 9A06
31 Center Drive, MSC 2560
Bethesda, MD 20892-2560
For information about NIDDK programs: 301.496.3583

The National Institutes of Health   Department of Health and Human Services   USA.gov is the U.S. government's official web portal to all federal, state, and local government web resources and services.  HONcode Seal - Link to the Health on the Net Foundation