Also called: Also called: Christmas disease, Factor IX deficiency, Factor VIII deficiency
Hemophilia is a rare inherited disorder in which the blood does not clot normally. About 18,000 people in the U.S. have hemophilia. Each year, about 400 babies are born with the disorder. Hemophilia usually occurs in males (with very rare exceptions).
People who have hemophilia may bleed for a long time after an injury or accident. They also may bleed into their knees, ankles and elbows. Bleeding in the joints causes pain and, if not treated, can lead to arthritis. Bleeding in the brain, a very serious complication of hemophilia, requires emergency treatment.
The main treatment is injecting the missing clotting factor into the bloodstream.
National Heart, Lung, and Blood Institute
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Genetics Home Reference: Hemophilia
(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=hemophilia
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Hemophilia(National Heart, Lung, and Blood Institute) - http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_what.html
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Frequently Asked Questions: Hemophilia(World Federation of Hemophilia) - http://www.wfh.org/index.asp?lang=EN&url=2/1/1_1_1_FAQ.htm
Also available in Spanish http://www.wfh.org/index_SP.asp?lang=SP&url=3/1/1_1_1_FAQ_SP.htm
- Hemophilia(Mayo Foundation for Medical Education and Research) - http://www.mayoclinic.com/print/hemophilia/DS00218/DSECTION=all&METHOD=print
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Hemophilia in Pictures(World Federation of Hemophilia) - Large PDF file - http://www.wfh.org/en/pdf/english.pdf
Also available in Spanish http://www.wfh.org/sp/pdf/espanol.pdf
- aPTT(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/aptt/test.html
- Coagulation Factors(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/coagulation_factors/test.html
- Fibrinogen(American Association for Clinical Chemistry) - http://www.labtestsonline.org/understanding/analytes/fibrinogen/test.html
- PT and INR(American Association for Clinical Chemistry) - http://labtestsonline.org/understanding/analytes/pt/test.html
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JAMA Patient Page: Blood Transfusion(American Medical Association) - http://jama.ama-assn.org/cgi/reprint/292/13/1646.pdf
Also available in Spanish http://jama.ama-assn.org/cgi/data/292/13/1646/DC1/1
- What Is Hemophilia?(Dolan DNA Learning Center) - Requires Flash Player - http://www.yourgenesyourhealth.org/hemo/whatisit.htm
- Bleeding Disorders: Financial and Insurance Issues(National Hemophilia Foundation) - http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=34&contentid=24
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ClinicalTrials.gov: Blood Coagulation Disorders(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Blood+Coagulation+Disorders%22
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ClinicalTrials.gov: Hemophilia A(National Institutes of Health) - http://clinicaltrials.gov/search/open/condition=%22Hemophilia+A%22
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Genetics Home Reference: Hemophilia(National Library of Medicine) - http://ghr.nlm.nih.gov/condition=hemophilia
References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Surgical evaluation of a recombinant factor VIII prepared using a... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18690340&tool=MedlinePlus
- Article: Haemophilia and inhibitors. 2: surgical management. - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18683391&tool=MedlinePlus
- Article: Controversies and challenges in elective orthopedic surgery in patients with... - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=18544428&tool=MedlinePlus
- Hemophilia -- see more articles - http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=(hemophilia+A[majr]+OR+hemophilia+B[majr])+AND+humans[mh]+AND+english[la]+AND+(review[pt]+OR+guideline[pt]+OR+clinical+trial[pt]+OR+jsubsetk[text]+OR+patient+education+handout[pt])+NOT+(editorial[pt]+OR+letter[pt])&doptcmdl=summary&cmd_current=Limits&pmfilter_EDatLimit=last+1+Year&tool=MedlinePlus
- Find a Hematologist(American Society of Hematology) - https://store.hematology.org/fah/fahhome.htm
- Find a Pediatric Hematologist/Oncologist(American Society of Pediatric Hematology/Oncology) - http://www.association-office.com/aspho/etools/publicdir/search.cfm
- Hemophilia Treatment Centers(Centers for Disease Control and Prevention) - http://www.cdc.gov/ncbddd/hbd/htc_list.htm
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National Heart, Lung, and Blood Institute - http://www.nhlbi.nih.gov/
- National Hemophilia Foundation - http://www.hemophilia.org/
- Hemophilia(Nemours Foundation) - http://kidshealth.org/parent/medical/heart/hemophilia.html
- How to Deal with Hemophilia(Nemours Foundation) - http://kidshealth.org/kid/health_problems/blood/hemophilia.html
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Blood Transfusions(Nemours Foundation) - http://kidshealth.org/teen/your_body/medical_care/transfusions.html
Also available in Spanish http://kidshealth.org/teen/en_espanol/cuerpo/transfusions_esp.html
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Hemophilia(Nemours Foundation) - http://kidshealth.org/teen/diseases_conditions/blood/hemophilia.html
Also available in Spanish http://kidshealth.org/teen/en_espanol/enfermedades/hemophilia_esp.html
- Bleeding Disorders - http://www.nlm.nih.gov/medlineplus/bleedingdisorders.html
- Blood, Heart and Circulation - http://www.nlm.nih.gov/medlineplus/bloodheartandcirculation.html
- Genetics/Birth Defects - http://www.nlm.nih.gov/medlineplus/geneticsbirthdefects.html
The primary NIH organization for research on Hemophilia is the National Heart, Lung, and Blood Institute - http://www.nhlbi.nih.gov/