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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th Edition
Laurence L. Brunton, editor-in-chief
John S. Lazo and Keith L. Parker, Associate Editors
Editors of the online edition:
Laurence L. Brunton, editor-in-chief
Associate Editors: Keith L. Parker, Nelda Murri, and Donald K. Blumenthal
In Memoriam
We are sad to report the death of our colleague and friend, Keith Parker. Keith suffered a myocardial infarction while jogging on December 1st. We will remember him for his energy, breadth of knowledge, and sparkling ideas. The obituary from the Dallas Morning News can be found here. We encourage interested readers to donate to the Keith Parker Memorial Fund at UT Southwestern, as noted in the obituary.
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Preface Preface to the Online
Edition Copyright Contributors
CONTENTS
| I. General Principles |
| Chapter 1. | Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Elimination |
| Chapter 2. | Membrane Transporters and Drug Response |
| Chapter 3. | Drug Metabolism |
| Chapter 4. | Pharmacogenetics |
| Chapter 5. | The Science of Drug Therapy
Latest Update: |
| II. Drugs Acting at Synaptic and Neuroeffector Junctional Sites |
| Chapter 6. | Neurotransmission: The Autonomic and Somatic Motor Nervous Systems
Video:
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| Chapter 7. | Muscarinic Receptor Agonists and Antagonists |
| Chapter 8. | Anticholinesterase Agents |
| Chapter 9. | Agents Acting at the Neuromuscular Junction and Autonomic Ganglia |
| Chapter 10. | Adrenergic Agonists and Antagonists |
| Chapter 11. | 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists |
| III. Drugs Acting on the Central Nervous System |
| Chapter 12. | Neurotransmission and the Central Nervous System |
| Chapter 13. | General Anesthetics |
| Chapter 14. | Local Anesthetics |
| Chapter 15. | Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium |
| Chapter 16. | Hypnotics and Sedatives |
| Chapter 17. | Drug Therapy of Depression and Anxiety Disorders |
| Chapter 18. | Pharmacotherapy of Psychosis and Mania |
| Chapter 19. | Pharmacotherapy of the Epilepsies
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| Chapter 20. | Treatment of Central Nervous System Degenerative Disorders
Video: |
| Chapter 21. | Opioid Analgesics |
| Chapter 22. | Ethanol |
| Chapter 23. | Drug Addiction and Drug Abuse |
| IV. Autacoids: Drug Therapy of Inflammation |
| Chapter 24. | Histamine, Bradykinin, and Their Antagonists |
| Chapter 25. | Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor |
| Chapter 26. | Analgesic-Antipyretic and Antiinflammatory Agents; Pharmacotherapy of Gout |
| Chapter 27. | Pharmacotherapy of Asthma |
| V. Drugs Affecting Renal and Cardiovascular Function |
| Chapter 28. | Diuretics |
| Chapter 29. | Vasopressin and Other Agents Affecting the Renal Conservation of Water |
| Chapter 30. | Renin and Angiotensin |
| Chapter 31. | Treatment of Myocardial Ischemia |
| Chapter 32. | Therapy of Hypertension |
| Chapter 33. | Pharmacotherapy of Congestive Heart Failure
Video: |
| Chapter 34. | Antiarrhythmic Drugs
Video:
Video:
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| Chapter 35. | Drug Therapy for Hypercholesterolemia and Dyslipidemia |
| VI. Drugs Affecting Gastrointestinal Function |
| Chapter 36. | Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease |
| Chapter 37. | Treatment of Disorders of Bowel Motility and Water Flux; Antiemetics; Agents Used in Biliary and Pancreatic Disease |
| Chapter 38. | Pharmacotherapy of Inflammatory Bowel Disease |
| VII. Chemotherapy of Parasitic Infections |
| Chapter 39. | Chemotherapy of Protozoal Infections: Malaria |
| Chapter 40. | Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections |
| Chapter 41. | Chemotherapy of Helminth Infections |
| VIII. Chemotherapy of Microbial Diseases |
| Chapter 42. | General Principles of Antimicrobial Therapy |
| Chapter 43. | Sulfonamides, Trimethoprim–Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections |
| Chapter 44. | Penicillins, Cephalosporins, and Other  -Lactam Antibiotics |
| Chapter 45. | Aminoglycosides |
| Chapter 46. | Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents |
| Chapter 47. | Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy
Latest Update: |
| Chapter 48. | Antimicrobial Agents: Antifungal Agents |
| Chapter 49. | Antiviral Agents (Nonretroviral) |
| Chapter 50. | Antiretroviral Agents and Treatment of HIV Infection |
| IX. Chemotherapy of Neoplastic Diseases |
| Chapter 51. | Antineoplastic Agents |
| X. Drugs Used for Immunomodulation |
| Chapter 52. | Immunosuppressants, Tolerogens, and Immunostimulants |
| XI. Drugs Acting on the Blood and the Blood-Forming Organs |
| Chapter 53. | Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
Latest Update: |
| Chapter 54. | Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs |
| XII. Hormones and Hormone Antagonists |
| Chapter 55. | Pituitary Hormones and Their Hypothalamic Releasing Hormones |
| Chapter 56. | Thyroid and Antithyroid Drugs |
| Chapter 57. | Estrogens and Progestins |
| Chapter 58. | Androgens |
| Chapter 59. | Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones |
| Chapter 60. | Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas |
| Chapter 61. | Agents Affecting Mineral Ion Homeostasis and Bone Turnover |
| XIII. Dermatology |
| Chapter 62. | Dermatological Pharmacology |
| XIV. Ophthalmology |
| Chapter 63. | Ocular Pharmacology |
| XV. Toxicology |
| Chapter 64. | Principles of Toxicology and Treatment of Poisoning |
| Chapter 65. | Heavy Metals and Heavy-Metal Antagonists |
| Appendices |
| Appendix I. | Principles of Prescription Order Writing and Patient Compliance |
| Appendix II. | Design and Optimization of Dosage Regimens: Pharmacokinetic Data |
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