Selective Bibliography of Dr. Kwok Kin Wong
Instructor, Department of Medicine, Harvard Medical School
Assistant Professor, Medicine, Harvard Medical School
Instructor, Adult Oncology, Dana-Farber Cancer Institute

"The Use of Genetically Engineered Mice for Preclinical Testing of Targeted Therapeutics"
Monday, May 19, 2008

1. Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Shapiro GI, Baum A, Himmelsbach F, Rettig WJ, Meyerson M, Solca F, Greulich H, Wong KK
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
ONCOGENE Apr 14 2008

2. Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer
CARCINOGENESIS 29 (4):747-753 Apr 2008

3. Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105 (6):2070-2075 Feb 12 2008

4. Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN, Schorge JO, Broaddus RR, Wong KK, Bardeesy N, Castrillon DH
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
CANCER RESEARCH 68 (3):759-766 Feb 1 2008

5. Engelman JA, Zejnullahu K, Gale CM, Lifshits E, Gonzales AJ, Shimamura T, Zhao F, Vincent PW, Naumov GN, Bradner JE, Althaus IW, Gandhi L, Shapiro GI, Nelson JM, Heymach JV, Meyerson M, Wong KK, Janne PA
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
CANCER RESEARCH 67 (24):11924-11932 Dec 15 2007

6. Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, Letai A
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion
CANCER RESEARCH 67 (24):11867-11875 Dec 15 2007

7. Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK
LKB1 modulates lung cancer differentiation and metastasis
NATURE 448 (7155):807-810 Aug 16 2007

8. Wong KK
HKI-272 in non small cell lung cancer
CLINICAL CANCER RESEARCH 13 (15 Pt 2):s4593-s4596 Aug 1 2007

9. Yuza Y, Glatt KA, Jiang J, Greulich H, Minami Y, Woo MS, Shimamura T, Shapiro G, Lee JC, Ji H, Feng W, Chen TH, Yanagisawa H, Wong KK, Meyerson M
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors
CANCER BIOLOGY & THERAPY 6 (5):661-667 May 2007

10. Thomas RK, Nickerson E, Simons JF, Janne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M, Sellers WR, Rothberg JM, Meyerson M
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
NATURE MEDICINE 12 (7):852-855 Jul 2006

Created 5/14/08